Template:2021 Major League Soccer Eastern Conference table
| Pos | Team | Pld | W | L | T | GF | GA | GD | Pts | Qualification |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | New England Revolution | 34 | 22 | 5 | 7 | 65 | 41 | +24 | 73 | Qualification for the playoffs conference semifinals and CONCACAF Champions League |
| 2 | Philadelphia Union | 34 | 14 | 8 | 12 | 48 | 35 | +13 | 54 | Qualification for the playoffs first round |
| 3 | Nashville SC | 34 | 12 | 4 | 18 | 55 | 33 | +22 | 54 | |
| 4 | New York City FC (C) | 34 | 14 | 11 | 9 | 56 | 36 | +20 | 51 | Qualification for the playoffs first round and CONCACAF Champions League[a] |
| 5 | Atlanta United FC | 34 | 13 | 9 | 12 | 45 | 37 | +8 | 51 | Qualification for the playoffs first round |
| 6 | Orlando City SC | 34 | 13 | 9 | 12 | 50 | 48 | +2 | 51 | |
| 7 | New York Red Bulls | 34 | 13 | 12 | 9 | 39 | 33 | +6 | 48 | |
| 8 | D.C. United | 34 | 14 | 15 | 5 | 56 | 54 | +2 | 47 | |
| 9 | Columbus Crew | 34 | 13 | 13 | 8 | 46 | 45 | +1 | 47 | |
| 10 | CF Montréal[b] | 34 | 12 | 12 | 10 | 46 | 44 | +2 | 46 | Qualification for the CONCACAF Champions League[c] |
| 11 | Inter Miami CF | 34 | 12 | 17 | 5 | 36 | 53 | −17 | 41 | |
| 12 | Chicago Fire FC | 34 | 9 | 18 | 7 | 36 | 54 | −18 | 34 | |
| 13 | Toronto FC[b] | 34 | 6 | 18 | 10 | 39 | 66 | −27 | 28 | |
| 14 | FC Cincinnati | 34 | 4 | 22 | 8 | 37 | 74 | −37 | 20 |
Source: MLS
Rules for classification: 1) points; 2) total wins; 3) total goal differential; 4) total goals scored; 5) fewer disciplinary points; 6) away goal differential; 7) away goals scored; 8) home goals differential; 9) home goals scored; 10) coin toss (2 clubs tied) or drawing of lots (≥3 clubs tied)
(C) Champions
Notes:
Rules for classification: 1) points; 2) total wins; 3) total goal differential; 4) total goals scored; 5) fewer disciplinary points; 6) away goal differential; 7) away goals scored; 8) home goals differential; 9) home goals scored; 10) coin toss (2 clubs tied) or drawing of lots (≥3 clubs tied)
(C) Champions
Notes:
- ^ As MLS Cup 2021 champions
- ^ a b Canadian clubs cannot qualify for the 2022 CONCACAF Champions League through the MLS regular season or playoffs.
- ^ As 2021 Canadian Championship winners