Limulus clotting factor B
| Limulus clotting factor B | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.85 | ||||||||
| CAS no. | 848851-53-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Limulus clotting factor B (EC 3.4.21.85) is an enzyme.[1] This enzyme catalyses the following chemical reaction:
- Selective cleavage of -Arg98-Ile99- bond in limulus proclotting enzyme to form active clotting enzyme
This enzyme is present in the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. In the immunity-related clotting pathways of these organisms, factor B is downstream of Limulus clotting factor C, but upstream of Limulus clotting enzyme.[2]
References
[edit]- ^ Nakamura T, Horiuchi T, Morita T, Iwanaga S (March 1986). "Purification and properties of intracellular clotting factor, factor B, from horseshoe crab (Tachypleus tridentatus) hemocytes". Journal of Biochemistry. 99 (3): 847–57. doi:10.1093/oxfordjournals.jbchem.a135545. PMID 3519594.
- ^ Iwanaga, S (May 2007). "Biochemical principle of Limulus test for detecting bacterial endotoxins". Proceedings of the Japan Academy. Series B, Physical and Biological Sciences. 83 (4): 110–9. Bibcode:2007PJAB...83..110I. doi:10.2183/pjab.83.110. PMC 3756735. PMID 24019589.
External links
[edit]- Limulus+clotting+factor+_overbar_B_ at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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