KLK13

KLK13kmpll
Identifiers
Aliases	KLK13, KLK-L4, KLKL4, kallikrein related peptidase 13
External IDs	OMIM: 605505; MGI: 3615275; HomoloGene: 56714; GeneCards: KLK13; OMA:KLK13 - orthologs
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,376,958 bp
RNA expression pattern
	n/a
	Top expressed in
	esophagus; ; lip; ; embryo; ; embryo; ; left lung lobe; ; hair follicle; ; zygote; ; stomach; ; external naris; ; oocyte;
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; serine-type peptidase activity; endopeptidase activity; serine-type endopeptidase activity; protein binding; hydrolase activity;
Cellular component	cytoplasm; extracellular region; extracellular space; secretory granule;
Biological process	cornification; proteolysis; protein processing;
	Sources:Amigo / QuickGO
Orthologs
	26085
	626834
	n/a
	ENSMUSG00000054046
	Q9UKR3; Q5BQ95; Q5BQ97
	n/a
	NM_015596
	NM_001039042
	NP_056411; NP_001335106; NP_001335107
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Kallikrein-13 is a protein that in humans is encoded by the KLK13 gene.^[4]^[5]^[6]

Function

Kallikreins are a subgroup of serine proteases having diverse physiological functions.

As of 2022, the precise physiological functions of Kallikrein 13 remain unknown. It may play a role in the defense of the upper digestive apparatus, in extracellular matrix degradation, in tissue remodelling, and in the male reproductive organs.

This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined.^[6]

Kallikrein-13 serves as a priming protease during infection by the human coronavirus HKU1.^[7]

Many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054046 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
^ "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. June 2006. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
^ ^a ^b "Entrez Gene: KLK13 kallikrein-related peptidase 13".
^ Milewska A, Falkowski K, Kulczycka M, Bielecka E, Naskalska A, Mak P, et al. (November 2020). "Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1". Science Signaling. 13 (659): eaba9902. doi:10.1126/scisignal.aba9902. PMC 7857416. PMID 33234691.{{cite journal}}: CS1 maint: article number as page number (link)

Diamandis EP, Yousef GM, Luo LY, Magklara A, Obiezu CV (March 2000). "The new human kallikrein gene family: implications in carcinogenesis". Trends in Endocrinology and Metabolism. 11 (2): 54–60. doi:10.1016/S1043-2760(99)00225-8. PMID 10675891. S2CID 25806934.
Yousef GM, Chang A, Diamandis EP (April 2000). "Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues". The Journal of Biological Chemistry. 275 (16): 11891–11898. doi:10.1074/jbc.275.16.11891. PMID 10766816.
Yousef GM, Chang A, Scorilas A, Diamandis EP (September 2000). "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4". Biochemical and Biophysical Research Communications. 276 (1): 125–133. doi:10.1006/bbrc.2000.3448. PMID 11006094.
Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, et al. (October 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–130. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
Chang A, Yousef GM, Jung K, Rajpert-De Meyts E, Diamandis EP (2002). "Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer". Anticancer Research. 21 (5): 3147–3152. PMID 11848466.
Chang A, Yousef GM, Scorilas A, Grass L, Sismondi P, Ponzone R, et al. (May 2002). "Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer". British Journal of Cancer. 86 (9): 1457–1464. doi:10.1038/sj.bjc.6600283. PMC 2375362. PMID 11986781.
Petraki CD, Karavana VN, Diamandis EP (April 2003). "Human kallikrein 13 expression in normal tissues: an immunohistochemical study". The Journal of Histochemistry and Cytochemistry. 51 (4): 493–501. doi:10.1177/002215540305100411. PMID 12642628.
Komatsu N, Takata M, Otsuki N, Toyama T, Ohka R, Takehara K, et al. (September 2003). "Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages". The Journal of Investigative Dermatology. 121 (3): 542–549. doi:10.1046/j.1523-1747.2003.12363.x. PMID 12925213.
Petraki CD, Gregorakis AK, Papanastasiou PA, Karavana VN, Luo LY, Diamandis EP (2004). "Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues". Prostate Cancer and Prostatic Diseases. 6 (3): 223–227. doi:10.1038/sj.pcan.4500674. PMID 12970725. S2CID 21609011.
Kapadia C, Yousef GM, Mellati AA, Magklara A, Wasney GA, Diamandis EP (January 2004). "Complex formation between human kallikrein 13 and serum protease inhibitors". Clinica Chimica Acta; International Journal of Clinical Chemistry. 339 (1–2): 157–167. doi:10.1016/j.cccn.2003.10.009. PMID 14687906.
Kapadia C, Ghosh MC, Grass L, Diamandis EP (October 2004). "Human kallikrein 13 involvement in extracellular matrix degradation". Biochemical and Biophysical Research Communications. 323 (3): 1084–1090. doi:10.1016/j.bbrc.2004.08.206. PMID 15381110.
Darling MR, Jackson-Boeters L, Daley TD, Diamandis EP (2006). "Human kallikrein 13 expression in salivary gland tumors". The International Journal of Biological Markers. 21 (2): 106–110. doi:10.1177/172460080602100206. PMID 16847813. S2CID 7038149.

External links

The MEROPS online database for peptidases and their inhibitors: S01.306^{[permanent dead link]}

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000054046 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Lundwall_2006-4] Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.

[pmid16800723-5] "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. June 2006. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.

[entrez-6] "Entrez Gene: KLK13 kallikrein-related peptidase 13".

[7] Milewska A, Falkowski K, Kulczycka M, Bielecka E, Naskalska A, Mak P, et al. (November 2020). "Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1". Science Signaling. 13 (659): eaba9902. doi:10.1126/scisignal.aba9902. PMC 7857416. PMID 33234691.{{cite journal}}: CS1 maint: article number as page number (link)

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KLK13

Function

References

Further reading

External links