KLK12

KLK12
Identifiers
Aliases	KLK12, KLK-L5, KLKL5, kallikrein related peptidase 12
External IDs	OMIM: 605539; MGI: 1916761; HomoloGene: 44690; GeneCards: KLK12; OMA:KLK12 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 51,029,092 bp[1] End 51,035,230 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.26 cM Start 43,418,321 bp[2] End 43,423,009 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums gingival epithelium oral cavity cervix epithelium mucosa of pharynx body of tongue superior surface of tongue vagina minor salivary glands amniotic fluid Top expressed in esophagus lip embryo stomach skin of external ear genital tubercle skin of back aorta ascending aorta nucleus of brain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity serine-type peptidase activity peptidase activity serine-type endopeptidase activity Cellular component extracellular region extracellular space secretory granule Biological process proteolysis cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 43849 69511 Ensembl ENSG00000186474 ENSMUSG00000044430 UniProt Q9UKR0 B2RVZ0 RefSeq (mRNA) NM_019598 NM_145894 NM_145895 NM_001370125 NM_001370126 NM_001370127 NM_001370128 NM_027097 RefSeq (protein) NP_062544 NP_665901 NP_665902 NP_001357054 NP_001357055 NP_001357056 NP_001357057 NP_081373 Location (UCSC) Chr 19: 51.03 – 51.04 Mb Chr 7: 43.42 – 43.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.^[5][6][7]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000186474 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044430 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
6. "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. June 2006. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
7. "Entrez Gene: KLK12 kallikrein-related peptidase 12".

Further reading

• Diamandis EP, Yousef GM, Luo LY, Magklara A, Obiezu CV (March 2000). "The new human kallikrein gene family: implications in carcinogenesis". Trends in Endocrinology and Metabolism. 11 (2): 54–60. doi:10.1016/S1043-2760(99)00225-8. PMID 10675891. S2CID 25806934.
• Yousef GM, Luo LY, Diamandis EP (2000). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4". Anticancer Research. 19 (4B): 2843–2852. PMID 10652563.
• Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA (December 2000). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". The Journal of Biological Chemistry. 275 (48): 37397–37406. doi:10.1074/jbc.M004525200. PMID 10969073.
• Yousef GM, Chang A, Scorilas A, Diamandis EP (September 2000). "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4". Biochemical and Biophysical Research Communications. 276 (1): 125–133. doi:10.1006/bbrc.2000.3448. PMID 11006094.
• Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, et al. (October 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–130. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
• Yousef GM, Magklara A, Diamandis EP (November 2000). "KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer". Genomics. 69 (3): 331–341. doi:10.1006/geno.2000.6346. PMID 11056051.
• Shinmura K, Tao H, Yamada H, Kataoka H, Sanjar R, Wang J, et al. (September 2004). "Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity". Human Mutation. 24 (3): 273–274. doi:10.1002/humu.9270. PMID 15300858. S2CID 39475520.
• Memari N, Jiang W, Diamandis EP, Luo LY (April 2007). "Enzymatic properties of human kallikrein-related peptidase 12 (KLK12)". Biological Chemistry. 388 (4): 427–435. doi:10.1515/BC.2007.049. PMID 17391064. S2CID 25034775.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.020^{[permanent dead link]}