KLK10

KLK10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SPJ
Identifiers
Aliases	KLK10, NES1, PRSSL1, kallikrein related peptidase 10
External IDs	OMIM: 602673; MGI: 1916790; HomoloGene: 26428; GeneCards: KLK10; OMA:KLK10 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 51,012,739 bp[1] End 51,020,175 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.26 cM Start 43,430,459 bp[2] End 43,434,834 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums gingival epithelium human penis mucosa of pharynx oral cavity vulva epithelium of esophagus skin of arm body of tongue skin of abdomen Top expressed in lip esophagus skin of external ear skin of back skin of abdomen cervix blastocyst embryo rectum stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component extracellular region secretory granule Biological process cell cycle proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5655 69540 Ensembl ENSG00000129451 ENSMUSG00000030693 UniProt O43240 Q99M20 RefSeq (mRNA) NM_001077500 NM_002776 NM_145888 NM_133712 RefSeq (protein) NP_001070968 NP_002767 NP_665895 NP_598473 Location (UCSC) Chr 19: 51.01 – 51.02 Mb Chr 7: 43.43 – 43.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene.^{[5][6][7][8][9]}

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000129451 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030693 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu XL, Wazer DE, Watanabe K, Band V (July 1996). "Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression". Cancer Research. 56 (14): 3371–3379. PMID 8764136.
6. Polikoff D, Kuo WL, Cochran JF, Wernick M, Kowbel D, Myambo K, et al. (Apr 1998). "Assignment of protease, serine-like 1 (PRSSL1) to human chromosome 19q13 by in situ hybridization and radiation hybrid mapping". Cytogenetics and Cell Genetics. 79 (1–2): 147–148. doi:10.1159/000134705. PMID 9533035.
7. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
8. "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. June 2006. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
9. "Entrez Gene: KLK10 kallikrein-related peptidase 10".

Further reading

• Diamandis EP, Yousef GM, Luo LY, Magklara A, Obiezu CV (March 2000). "The new human kallikrein gene family: implications in carcinogenesis". Trends in Endocrinology and Metabolism. 11 (2): 54–60. doi:10.1016/S1043-2760(99)00225-8. PMID 10675891. S2CID 25806934.
• Zhang Y, Bhat I, Zeng M, Jayal G, Wazer DE, Band H, et al. (June 2006). "Human kallikrein 10, a predictive marker for breast cancer". Biological Chemistry. 387 (6): 715–721. doi:10.1515/BC.2006.090. PMID 16800732. S2CID 1962156.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Luo L, Herbrick JA, Scherer SW, Beatty B, Squire J, Diamandis EP (June 1998). "Structural characterization and mapping of the normal epithelial cell-specific 1 gene". Biochemical and Biophysical Research Communications. 247 (3): 580–586. Bibcode:1998BBRC..247..580L. doi:10.1006/bbrc.1998.8793. PMID 9647736.
• Goyal J, Smith KM, Cowan JM, Wazer DE, Lee SW, Band V (November 1998). "The role for NES1 serine protease as a novel tumor suppressor". Cancer Research. 58 (21): 4782–4786. PMID 9809976.
• Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA (December 2000). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". The Journal of Biological Chemistry. 275 (48): 37397–37406. doi:10.1074/jbc.M004525200. PMID 10969073.
• Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, et al. (October 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–130. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
• Dhar S, Bhargava R, Yunes M, Li B, Goyal J, Naber SP, et al. (November 2001). "Analysis of normal epithelial cell specific-1 (NES1)/kallikrein 10 mRNA expression by in situ hybridization, a novel marker for breast cancer". Clinical Cancer Research. 7 (11): 3393–3398. PMID 11705853.
• Bharaj BB, Luo LY, Jung K, Stephan C, Diamandis EP (April 2002). "Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK10) gene and their association with prostate, breast, testicular, and ovarian cancers". The Prostate. 51 (1): 35–41. doi:10.1002/pros.10076. PMID 11920956. S2CID 27003835.
• Luo LY, Diamandis EP, Look MP, Soosaipillai AP, Foekens JA (June 2002). "Higher expression of human kallikrein 10 in breast cancer tissue predicts tamoxifen resistance". British Journal of Cancer. 86 (11): 1790–1796. doi:10.1038/sj.bjc.6600323. PMC 2375391. PMID 12087468.
• Petraki CD, Karavana VN, Luo LY, Diamandis EP (September 2002). "Human kallikrein 10 expression in normal tissues by immunohistochemistry". The Journal of Histochemistry and Cytochemistry. 50 (9): 1247–1261. doi:10.1177/002215540205000912. PMID 12185203.
• Petraki CD, Gregorakis AK, Papanastasiou PA, Karavana VN, Luo LY, Diamandis EP (2004). "Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues". Prostate Cancer and Prostatic Diseases. 6 (3): 223–227. doi:10.1038/sj.pcan.4500674. PMID 12970725. S2CID 21609011.
• Sauter ER, Lininger J, Magklara A, Hewett JE, Diamandis EP (February 2004). "Association of kallikrein expression in nipple aspirate fluid with breast cancer risk". International Journal of Cancer. 108 (4): 588–591. doi:10.1002/ijc.11607. PMID 14696124. S2CID 29116787.
• Diamandis EP, Scorilas A, Kishi T, Blennow K, Luo LY, Soosaipillai A, et al. (March 2004). "Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia". Clinical Biochemistry. 37 (3): 230–237. doi:10.1016/j.clinbiochem.2003.11.012. PMID 14972646.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.246^{[permanent dead link]}