KLK11

KLK11
Identifiers
Aliases	KLK11, PRSS20, TLSP, kallikrein related peptidase 11
External IDs	OMIM: 604434; MGI: 1929977; HomoloGene: 27048; GeneCards: KLK11; OMA:KLK11 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.41 Start 51,022,216 bp[1] End 51,028,039 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 43,424,028 bp[2] End 43,428,687 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium skin of abdomen skin of arm skin of leg human penis oral cavity mucosa of pharynx vulva cervix epithelium gallbladder Top expressed in lip esophagus skin of external ear embryo skin of back embryo genital tubercle umbilical cord skin of abdomen trachea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity Cellular component extracellular region Golgi apparatus extracellular exosome extracellular space secretory granule Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11012 56538 Ensembl ENSG00000167757 ENSMUSG00000067616 UniProt Q9UBX7 Q9QYN3 RefSeq (mRNA) NM_001136032 NM_001167605 NM_006853 NM_144947 NM_001177373 NM_019974 RefSeq (protein) NP_001129504 NP_001161077 NP_006844 NP_659196 NP_001170844 NP_064358 Location (UCSC) Chr 19: 51.02 – 51.03 Mb Chr 7: 43.42 – 43.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.^{[5][6][7][8][9]}

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000167757 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067616 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S (August 1998). "cDNA cloning and expression of a novel serine protease, TLSP". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1399 (2–3): 225–228. doi:10.1016/s0167-4781(98)00116-x. PMID 9765601.
6. Yousef GM, Scorilas A, Diamandis EP (January 2000). "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family". Genomics. 63 (1): 88–96. doi:10.1006/geno.1999.6072. PMID 10662548.
7. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (June 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biological Chemistry. 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
8. "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. June 2006. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
9. "Entrez Gene: KLK11 kallikrein-related peptidase 11".

Further reading

• Mitsui S, Yamada T, Okui A, Kominami K, Uemura H, Yamaguchi N (May 2000). "A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate". Biochemical and Biophysical Research Communications. 272 (1): 205–211. Bibcode:2000BBRC..272..205M. doi:10.1006/bbrc.2000.2761. PMID 10872828.
• Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, et al. (October 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–130. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
• Nakamura T, Mitsui S, Okui A, Kominami K, Nomoto T, Ukimura O, et al. (September 2001). "Alternative splicing isoforms of hippostasin (PRSS20/KLK11) in prostate cancer cell lines". The Prostate. 49 (1): 72–78. doi:10.1002/pros.1119. PMID 11550212. S2CID 21572408.
• Diamandis EP, Okui A, Mitsui S, Luo LY, Soosaipillai A, Grass L, et al. (January 2002). "Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma". Cancer Research. 62 (1): 295–300. PMID 11782391.
• Nakamura T, Mitsui S, Okui A, Miki T, Yamaguchi N (March 2003). "Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate". The Prostate. 54 (4): 299–305. doi:10.1002/pros.10191. PMID 12539228. S2CID 21482369.
• Nakamura T, Stephan C, Scorilas A, Yousef GM, Jung K, Diamandis EP (May 2003). "Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues". Urology. 61 (5): 1042–1046. doi:10.1016/S0090-4295(02)02443-3. PMID 12736044.
• Borgoño CA, Fracchioli S, Yousef GM, Rigault de la Longrais IA, Luo LY, Soosaipillai A, et al. (September 2003). "Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma". International Journal of Cancer. 106 (4): 605–610. CiteSeerX 10.1.1.623.9575. doi:10.1002/ijc.11296. PMID 12845660. S2CID 13671141.

\* Shigemasa K, Gu L, Tanimoto H, O'Brien TJ, Ohama K (April 2004). "Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer". Clinical Cancer Research. 10 (8): 2766–2770. doi:10.1158/1078-0432.CCR-03-0269. PMID 15102682. S2CID 1192794.

• Diamandis EP, Borgoño CA, Scorilas A, Harbeck N, Dorn J, Schmitt M (September 2004). "Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients". Clinical Biochemistry. 37 (9): 823–829. doi:10.1016/j.clinbiochem.2004.04.009. PMID 15329323.
• Stavropoulou P, Gregorakis AK, Plebani M, Scorilas A (July 2005). "Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer". Clinica Chimica Acta; International Journal of Clinical Chemistry. 357 (2): 190–195. doi:10.1016/j.cccn.2005.03.026. PMID 15893744.
• Planque C, Aïnciburu M, Heuzé-Vourc'h N, Régina S, de Monte M, Courty Y (June 2006). "Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues". Biological Chemistry. 387 (6): 783–788. doi:10.1515/BC.2006.098. PMID 16800740. S2CID 6937753.
• Mitsui S, Nakamura T, Okui A, Kominami K, Uemura H, Yamaguchi N (August 2006). "Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin". The FEBS Journal. 273 (16): 3678–3686. doi:10.1111/j.1742-4658.2006.05372.x. PMID 16911518. S2CID 25021929.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.257^{[permanent dead link]}