KLK15

KLK15
Identifiers
Aliases	KLK15, ACO, HSRNASPH, kallikrein related peptidase 15
External IDs	OMIM: 610601; MGI: 2447533; HomoloGene: 77571; GeneCards: KLK15; OMA:KLK15 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 50,825,289 bp[1] End 50,837,213 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 28.41 cM Start 43,583,164 bp[2] End 43,589,063 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava tendon of biceps brachii Skeletal muscle tissue of rectus abdominis cerebellar vermis parotid gland body of tongue buccal mucosa cell right ventricle pons pericardium Top expressed in lip embryo secondary oocyte primary oocyte zygote placenta spermatid genital tubercle zone of skin right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity protein binding hydrolase activity serine-type endopeptidase activity Cellular component extracellular region secretory granule Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55554 317652 Ensembl ENSG00000174562 ENSMUSG00000055193 UniProt Q9H2R5 n/a RefSeq (mRNA) NM_001277081 NM_001277082 NM_017509 NM_023006 NM_138563 NM_138564 NM_174865 RefSeq (protein) NP_001264010 NP_001264011 NP_059979 n/a Location (UCSC) Chr 19: 50.83 – 50.84 Mb Chr 7: 43.58 – 43.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.^{[5][6][7][8][9]}

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000174562 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055193 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yousef GM, Scorilas A, Jung K, Ashworth LK, Diamandis EP (Feb 2001). "Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer". Journal of Biological Chemistry. 276 (1): 53–61. doi:10.1074/jbc.M005432200. PMID 11010966.
6. Yousef GM, Scorilas A, Magklara A, Memari N, Ponzone R, Sismondi P, et al. (Nov 2002). "The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer". Br J Cancer. 87 (11): 1294–1300. doi:10.1038/sj.bjc.6600590. PMC 2408911. PMID 12439720.
7. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biol Chem. 387 (6): 637–641. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
8. Diamandis EP, Deperthes D, Lundwall Å (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3, 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
9. "Entrez Gene: KLK15 kallikrein-related peptidase 15".

Further reading

• Diamandis EP, Yousef GM, Luo LY, Magklara A, Obiezu CV (Mar 2000). "The new human kallikrein gene family: implications in carcinogenesis". Trends Endocrinol. Metab. 11 (2): 54–60. doi:10.1016/S1043-2760(99)00225-8. PMID 10675891. S2CID 25806934.
• Diamandis EP, Yousef GM (Jul 2001). "Human tissue kallikrein gene family: a rich source of novel disease biomarkers". Expert Rev. Mol. Diagn. 1 (2): 182–190. doi:10.1586/14737159.1.2.182. PMID 11901813. S2CID 35323809.
• Dihanich M, Spiess M (Jun 1994). "A novel serine proteinase-like sequence from human brain". Biochim. Biophys. Acta. 1218 (2): 225–228. doi:10.1016/0167-4781(94)90018-3. PMID 8018728.
• Yousef GM, Chang A, Scorilas A, Diamandis EP (Sep 2000). "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4". Biochem. Biophys. Res. Commun. 276 (1): 125–133. Bibcode:2000BBRC..276..125Y. doi:10.1006/bbrc.2000.3448. PMID 11006094.
• Gan L, Lee I, Smith R, Argonza-Barrett R, Lei H, McCuaig J, et al. (Oct 2000). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–130. doi:10.1016/S0378-1119(00)00382-6. PMID 11054574.
• Takayama TK, Carter CA, Deng T (Feb 2001). "Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR". Biochemistry. 40 (6): 1679–1687. doi:10.1021/bi002129r. PMID 11327827.
• Yousef GM, Scorilas A, Katsaros D, Fracchioli S, Iskander L, Borgono C, et al. (Aug 2003). "Prognostic value of the human kallikrein gene 15 expression in ovarian cancer". J. Clin. Oncol. 21 (16): 3119–3126. doi:10.1200/JCO.2003.09.111. PMID 12915603.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2) R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.

External links

• The MEROPS online database for peptidases and their inhibitors: S01.081^{[permanent dead link]}