Renanolone

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Renanolone
Clinical data
ATC code
  • none
Identifiers
  • 3α-hydroxy-5β-pregnane-11,20-dione
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H32O3
Molar mass332.484 g·mol−1
3D model (JSmol)
  • CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)C
  • InChI=InChI=1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14-,15+,16-,17+,19-,20+,21-/m1/s1
  • Key:DUHUCHOQIDJXAT-CSXWOMMHSA-N

Renanolone (INN; also known as 11-ketopregnanolone or 5β-pregnan-3α-ol-11,20-dione) is a synthetic[citation needed] neuroactive steroid which is described as a general anesthetic, but was never introduced for clinical use.[1] Its isomers, alfaxolone and alfadolone, are also general anesthetics, and are known to act as positive allosteric modulators of the GABAA receptor, a property which is likely the case for renanolone as well.

Chemistry

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See also: List of neurosteroids

See also

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References

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  1. ^ Hill RA, Makin HL, Kirk DN, Murphy GM (23 May 1991). Dictionary of Steroids. CRC Press. p. 592. ISBN 978-0-412-27060-4.



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