WHO Model List of Essential Medicines
The WHO Model List of Essential Medicines (a.k.a. Essential Medicines List or EML[1]), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system.[2] The list is frequently used by countries to help develop their own local lists of essential medicines.[2] As of 2016[update], more than 155 countries have created national lists of essential medicines based on the World Health Organization's model list.[1] This includes both developed and developing countries.[2][3]
The list is divided into core items and complementary items.[4] The core items are deemed to be the most cost-effective options for key health problems and are usable with little additional health care resources.[4] The complementary items either require additional infrastructure such as specially trained health care providers or diagnostic equipment or have a lower cost–benefit ratio.[4] About 25% of items are in the complementary list.[5] Some medications are listed as both core and complementary.[6] While most medications on the list are available as generic products, being under patent does not preclude inclusion.[7]
The first list was published in 1977 and included 208 medications.[8][2][9] The WHO updates the list every two years.[10] There are 306 medications in the 14th list in 2005,[11] 410 in the 19th list in 2015,[10] 433 in the 20th list in 2017,[12][13] 460 in the 21st list in 2019,[14][15][16] and 479 in the 22nd list in 2021.[17][18] Various national lists contain between 334 and 580 medications.[5][19] The Essential Medicines List (EML) was updated in September 2025 to its 24th edition.[20] The list contains recommendations for 523 medications.
A separate list for children up to twelve years of age, known as the WHO Model List of Essential Medicines for Children (EMLc), was created in 2007, and is in its 10th edition.[10][21][22][23][24] It was created to make sure that the needs of children were systematically considered such as availability of proper formulations.[25][26] Everything in the children's list is also included in the main list.[27] The list and notes are based on the 19th to 24th edition of the main list.[4][12][14][17][28] Therapeutic alternatives with similar clinical performance are listed for some medicines and they may be considered for national essential medicines lists.[17][18] The 10th Essential Medicines List for Children was updated in September 2025.[24][29][30]
Note: An α indicates a medicine is on the complementary list.[4][14][17]
Anaesthetics, preoperative medicines and medical gases
[edit]General anaesthetics and oxygen
[edit]Inhalational medicines
[edit]Injectable medicines
[edit]Local anaesthetics
[edit]Complementary:
Preoperative medication and sedation for short-term procedures
[edit]Medical gases
[edit]Medicines for pain and palliative care
[edit]Non-opioids and non-steroidal anti-inflammatory medicines (NSAIMs)
[edit]
- Acetylsalicylic acid (aspirin)
- Ibuprofen[note 5]
- Paracetamol (acetaminophen)[note 6]
Opioid analgesics
[edit]Complementary:
Medicines for other common symptoms in palliative care
[edit]- Amitriptyline
- Cyclizine
- Dexamethasone
- Diazepam
- Docusate sodium
- Fluoxetine
- Haloperidol
- Hyoscine butylbromide
- Hyoscine hydrobromide
- Lactulose
- Loperamide
- Metoclopramide
- Midazolam[note 10]
- Ondansetron[note 11]
- Senna
Antiallergics and medicines used in anaphylaxis
[edit]Antidotes and other substances used in poisonings
[edit]Non-specific
[edit]Specific
[edit]- Acetylcysteine
- Atropine
- Calcium gluconate
- Methylthioninium chloride (methylene blue)
- Naloxone
- Penicillamine
- Potassium ferric hexacyano-ferrate(II) -2H2O (prussian blue)
- Sodium nitrite
- Sodium thiosulfate
Complementary:
Medicines for neurological disorders
[edit]Medicines for central nervous system disorders
[edit]Antiseizure medicines
[edit]- Carbamazepine
- Diazepam
- Lamotrigine[note 15]
- Levetiracetam
- Lorazepam[note 16]
- Magnesium sulfate[note 17]
- Midazolam[note 10]
- Phenobarbital
- Phenytoin[note 18]
- Valproic acid (sodium valproate)[note 19]
Complementary:
- Ethosuximideα
- Levetiracetamα
- Valproic acid (sodium valproate)α[note 19]
Medicines for multiple sclerosis
[edit]Complementary:
Medicines for parkinsonism
[edit]Medicines for cerebral palsy
[edit]Medicines for headache disorders
[edit]Medicines for acute migraine attacks
[edit]- Acetylsalicylic acid (aspirin)
- Ibuprofen[note 23]
- Paracetamol (acetaminophen)[note 24]
- Sumatriptan[note 25]
Medicines for migraine prophylaxis
[edit]Medicines for cluster headache
[edit]Medicines for central nervous system infections
[edit]Medicines for bacterial central nervous system infections
[edit]- Amoxicillin
- Ampicillin
- Benzylpenicillin
- Cefotaxime[note 26]
- Ceftriaxone[note 27][note 28]
- Chloramphenicol[note 29]
- Gentamicin
Complementary:
Medicines for viral central nervous system infections
[edit]Medicines for peripheral nervous system disorders
[edit]Medicines for Guillain-Barré syndrome
[edit]Complementary:
Medicines for myasthenia gravis
[edit]Complementary:
Anti-infective medicines
[edit]Anthelminthics
[edit]Intestinal anthelminthics
[edit]
Antifilarials
[edit]Antischistosomals and other antinematode medicines
[edit]Complementary:
Cysticidal medicines
[edit]Complementary:
Antibacterials
[edit]Access group antibiotics
[edit]- Amikacin
- Amoxicillin
- Amoxicillin/clavulanic acid (amoxicillin + clavulanic acid)
- Ampicillin
- Benzathine benzylpenicillin
- Benzylpenicillin
- Cefalexin
- Cefazolin[note 35]
- Chloramphenicol[note 36]
- Clindamycin
- Cloxacillin[note 37][note 38]
- Doxycycline[note 39]
- Gentamicin
- Metronidazole
- Nitrofurantoin
- Phenoxymethylpenicillin (penicillin V)
- Procaine benzylpenicillin[note 40]
- Spectinomycin
- Sulfamethoxazole/trimethoprim (sulfamethoxazole + trimethoprim)
- Trimethoprim
Watch group antibiotics
[edit]- Azithromycin
- Cefixime
- Cefotaxime[note 41]
- Ceftriaxone[note 27][note 28]
- Cefuroxime
- Ciprofloxacin
- Clarithromycin[note 42][note 43]
- Piperacillin/tazobactam (piperacillin + tazobactam)
- Vancomycin[note 44]
Complementary:
Reserve group antibiotics
[edit]Complementary:
- Cefiderocolα
- Ceftazidime/avibactam (ceftazidime + avibactam)α
- Ceftolozane/tazobactam (ceftolozane + tazobactam)α
- Colistinα
- Fosfomycinα
- Linezolidα[note 46]
- Meropenem/vaborbactam (meropenem + vaborbactam)α
- Plazomicinα
- Polymyxin Bα
Antileprosy medicines
[edit]Antituberculosis medicines
[edit]
- Amikacin
- Amoxicillin/clavulanic acid (amoxicillin + clavulanic acid)[note 47]
- Bedaquiline
- Clofazimine
- Cycloserine[note 48]
- Delamanid
- Ethambutol
- Ethambutol/isoniazid/pyrazinamide/rifampicin (ethambutol + isoniazid + pyrazinamide + rifampicin)
- Ethambutol/isoniazid/rifampicin (ethambutol + isoniazid + rifampicin)
- Ethionamide[note 49]
- Isoniazid
- Isoniazid/pyrazinamide/rifampicin (isoniazid + pyrazinamide + rifampicin)
- Isoniazid/rifampicin (isoniazid + rifampicin)
- Isoniazid/rifapentine (isoniazid + rifapentine)
- Levofloxacin
- Linezolid
- Meropenem[note 50]
- Moxifloxacin
- Moxifloxacin
- P-aminosalicylic acid (p-aminosalicylate sodium)
- Pretomanid
- Pyrazinamide
- Rifabutin
- Rifampicin
- Rifapentine
- Streptomycin
Antifungal medicines
[edit]- Amphotericin B
- Clotrimazole
- Fluconazole
- Flucytosine
- Griseofulvin
- Itraconazole[note 51]
- Nystatin
- Voriconazole[note 52]
Complementary:
Antiviral medicines
[edit]Antiherpes medicines
[edit]Antiretrovirals
[edit]Nucleoside/nucleotide reverse transcriptase inhibitors
[edit]Non-nucleoside reverse transcriptase inhibitors
[edit]Protease inhibitors
[edit]- Atazanavir/ritonavir (atazanavir + ritonavir)
- Darunavir[note 56]
- Lopinavir/ritonavir (lopinavir + ritonavir)
- Ritonavir
Integrase inhibitors
[edit]Fixed-dose combinations of antiretroviral medicines
[edit]- Abacavir/dolutegravir/lamivudine (abacavir + dolutegravir + lamivudine)
- Abacavir/lamivudine (abacavir + lamivudine)
- Dolutegravir/lamivudine/tenofovir (dolutegravir + lamivudine + tenofovir)
- Efavirenz/emtricitabine/tenofovir[note 59]
- Efavirenz/lamivudine/tenofovir (efavirenz + lamivudine + tenofovir)
- Emtricitabine/tenofovir (emtricitabine + tenofovir)[note 59][note 60]
- Lamivudine/zidovudine (lamivudine + zidovudine)
Medicines for prevention of HIV-related opportunistic infections
[edit]- Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim (isoniazid + pyridoxine + sulfamethoxazole + trimethoprim)
Other antivirals
[edit]Complementary:
Antihepatitis medicines
[edit]Medicines for hepatitis B
[edit]Nucleoside/Nucleotide reverse transcriptase inhibitors
[edit]Medicines for hepatitis C
[edit]Pangenotypic direct-acting antiviral combinations
[edit]- Daclatasvir[note 64]
- Daclatasvir/sofosbuvir (daclatasvir + sofosbuvir)
- Glecaprevir/pibrentasvir (glecaprevir + pibrentasvir)
- Ravidasvir[note 65]
- Sofosbuvir[note 66]
- Sofosbuvir/velpatasvir (sofosbuvir + velpatasvir)
Non-pangenotypic direct-acting antiviral combinations
[edit]Other antivirals for hepatitis C
[edit]Antiprotozoal medicines
[edit]Antiamoebic and antigiardiasis medicines
[edit]Antileishmaniasis medicines
[edit]Antimalarial medicines
[edit]Medicines for curative treatment
[edit]- Artemether[note 72]
- Artemether/lumefantrine (artemether + lumefantrine)
- Artesunate[note 72]
- Artesunate/amodiaquine (artesunate + amodiaquine)
- Artesunate/mefloquine (artesunate + mefloquine)
- Artesunate/pyronaridine tetraphosphate (artesunate + pyronaridine tetraphosphate)
- Artesunate + sulfadoxine/pyrimethamine (Co-packaged)
- Chloroquine[note 73]
- Dihydroartemisinin/piperaquine phosphate (dihydroartemisinin + piperaquine phosphate)
- Primaquine[note 74]
- Quinine[note 72]
Medicines for chemoprevention
[edit]- Amodiaquine + sulfadoxine/pyrimethamine (Co-packaged)
- Sulfadoxine/pyrimethamine (sulfadoxine + pyrimethamine)
Medicines for chemoprophylaxis in travellers
[edit]Antipneumocystosis and antitoxoplasmosis medicines
[edit]Complementary:
Antitrypanosomal medicines
[edit]African trypanosomiasis
[edit]Medicines for the treatment of 1st stage African trypanosomiasis
[edit]Medicines for the treatment of 2nd stage African trypanosomiasis
[edit]Complementary:
American trypanosomiasis
[edit]Medicines for ectoparasitic infections
[edit]Medicines for Ebola virus disease
[edit]Medicines for COVID-19
[edit]No listings in this section.
Medicines for cystic fibrosis
[edit]Complementary:
Immunomodulators and antineoplastics
[edit]Immunomodulators for non-malignant disease
[edit]Complementary:
Antineoplastics and supportive medicines
[edit]Cytotoxic medicines
[edit]Complementary:
- Arsenic trioxideα
- Asparaginaseα[note 20]
- Bendamustineα
- Bleomycinα
- Calcium folinate (leucovorin calcium)α
- Capecitabineα
- Carboplatinα
- Chlorambucilα
- Cisplatinα
- Cyclophosphamideα
- Cytarabineα
- Dacarbazineα
- Dactinomycinα
- Daunorubicinα
- Docetaxelα
- Doxorubicinα
- Doxorubicin (as pegylated liposomal)α
- Etoposideα
- Fludarabineα
- Fluorouracilα
- Gemcitabineα
- Hydroxycarbamide (hydroxyurea)α
- Ifosfamideα
- Irinotecanα
- Melphalanα
- Mercaptopurineα
- Methotrexateα
- Oxaliplatinα
- Paclitaxelα
- Pegaspargaseα[note 20]
- Procarbazineα
- Realgar Indigo naturalis formulationα
- Tioguanineα
- Vinblastineα
- Vincristineα
- Vinorelbineα
Targeted therapies
[edit]Complementary:
- All-trans retinoic acid (tretinoin) (ATRA)α
- Bortezomibα
- Dasatinibα
- Erlotinibα[note 82]
- Everolimusα
- Ibrutinibα[note 83]
- Imatinibα
- Nilotinibα
- Rituximabα[note 20]
- Trastuzumabα[note 20]
Immunomodulators
[edit]Complementary:
- Blinatumomabα[note 20]
- Filgrastimα[note 20]
- Lenalidomideα
- Pegfilgrastimα[note 20]
- Pembrolizumabα[note 20][note 84]
- Pembrolizumabα[note 85]
- Pembrolizumabα[note 86]
- Thalidomideα
Hormones and antihormones
[edit]Complementary:
- Abirateroneα[note 87]
- Anastrozoleα[note 88]
- Bicalutamideα[note 89]
- Dexamethasoneα
- Hydrocortisoneα
- Leuprorelinα[note 90]
- Methylprednisoloneα
- Prednisoloneα[note 13]
- Tamoxifenα
Supportive medicines
[edit]Complementary:
Therapeutic foods
[edit]Medicines affecting the blood
[edit]Antianaemia medicines
[edit]- Ferrous salt
- Ferrous salt/folic acid (ferrous salt + folic acid)
- Folic acid[note 93]
- Hydroxocobalamin
Complementary:
Medicines affecting coagulation
[edit]- Dabigatran[note 95]
- Desmopressin
- Emicizumab
- Enoxaparin[note 96]
- Heparin sodium
- Phytomenadione
- Protamine sulfate
- Tranexamic acid
- Warfarin[note 97]
Complementary:
Medicines for haemoglobinopathies
[edit]Medicines for sickle-cell disease
[edit]- Deferasirox[note 98]
- Hydroxyurea (hydroxycarbamide)
Complementary:
Medicines for thalassaemias
[edit]Complementary:
Blood products, coagulation factors and plasma substitutes
[edit]Blood and blood components
[edit]- Cryoprecipitate, pathogen-reduced[note 99]
- Fresh frozen plasma
- Platelets
- Red blood cells
- Whole blood
Human immunoglobulins
[edit]Complementary:
Coagulation factors
[edit]- Coagulation factor VIII, plasma-derived
- Coagulation factor IX, plasma-derived
- Coagulation factor VIII, recombinant
- Coagulation factor IX, recombinant
Plasma substitutes
[edit]Cardiovascular medicines
[edit]Antianginal medicines
[edit]Antiarrhythmic medicines
[edit]- Bisoprolol[note 101]
- Digoxin
- Epinephrine (adrenaline)
- Lidocaine
- Verapamil
Complementary:
Antihypertensive medicines
[edit]- Amlodipine[note 102]
- Bisoprolol[note 103]
- Enalapril[note 104]
- Hydralazine[note 105]
- Hydrochlorothiazide[note 106]
- Lisinopril/amlodipine (lisinopril + amlodipine)[note 107]
- Lisinopril/hydrochlorothiazide (lisinopril + hydrochlorothiazide)[note 108]
- Losartan[note 109]
- Methyldopa[note 110]
- Perindopril/amlodipine/indapamide (perindopril + amlodipine + indapamide)[note 111]
- Telmisartan/amlodipine (telmisartan + amlodipine)[note 112]
- Telmisartan/hydrochlorothiazide (telmisartan + hydrochlorothiazide)[note 113]
- Valsartan/amlodipine/hydrochlorothiazide (valsartan + amlodipine + hydrochlorothiazide)[note 114]
Complementary:
Medicines used in heart failure
[edit]- Bisoprolol[note 101]
- Digoxin
- Enalapril[note 115]
- Furosemide[note 116]
- Hydrochlorothiazide[note 106]
- Losartan[note 109]
- Spironolactone
Complementary:
Antithrombotic medicines
[edit]Anti-platelet medicines
[edit]- Acetylsalicylic acid (aspirin)
- Clopidogrel
Thrombolytic medicines
[edit]Complementary:
Lipid-lowering agents
[edit]Fixed-dose combinations for prevention of atherosclerotic cardiovascular disease
[edit]- Acetylsalicylic acid/atorvastatin/ramipril (acetylsalicylic acid + atorvastatin + ramipril)[note 118][note 119]
- Acetylsalicylic acid/simvastatin/ramipril/atenolol/hydrochlorothiazide (acetylsalicylic acid + simvastatin + ramipril + atenolol + hydrochlorothiazide)[note 120][note 119][note 121][note 122]
- Atorvastatin/perindopril/amlodipine (atorvastatin + perindopril + amlodipine)[note 118][note 123][note 124]
Dermatological medicines
[edit]Antifungal medicines
[edit]Anti-infective medicines
[edit]Anti-inflammatory and antipruritic medicines
[edit]Medicines affecting skin differentiation and proliferation
[edit]- Benzoyl peroxide
- Calcipotriol[note 128]
- Coal tar
- Fluorouracil
- Podophyllum resin[note 129]
- Salicylic acid
- Urea
Complementary:
Scabicides and pediculicides
[edit]Moisturizers
[edit]Sunscreens, broad-spectrum
[edit]Diagnostic agents
[edit]Ophthalmic medicines
[edit]Radiocontrast media
[edit]Complementary:
Antiseptics and disinfectants
[edit]Antiseptics
[edit]Disinfectants
[edit]Diuretics
[edit]Complementary:
Gastrointestinal medicines
[edit]Complementary:
Antiulcer medicines
[edit]Antiemetic medicines
[edit]Complementary:
Anti-inflammatory medicines
[edit]Complementary:
Laxatives
[edit]Medicines used in diarrhoea
[edit]- Oral rehydration salts + zinc sulfate (Co-packaged)
Oral rehydration
[edit]Medicines for diarrhoea
[edit]Medicines for endocrine disorders
[edit]Adrenal hormones and synthetic substitutes
[edit]Androgens
[edit]Complementary:
Estrogens
[edit]No listings in this section.
Progestogens
[edit]Medicines for diabetes
[edit]Insulins
[edit]- Insulin (analogue, long-acting)[note 144]
- Insulin (analogue, rapid-acting)[note 145]
- Insulin (human, intermediate-acting)[note 20]
- Insulin (human, short-acting)[note 20]
Hypoglycaemic agents
[edit]Complementary:
Medicines for hypoglycaemia
[edit]Complementary:
Thyroid hormones and antithyroid medicines
[edit]Complementary:
- Iodine + potassium iodide (Lugol's solution)α
- Methimazoleα[note 149]
- Potassium iodideα
- Propylthiouracilα[note 151]
Medicines for disorders of the pituitary hormone system
[edit]Complementary:
Immunologicals
[edit]Diagnostic agents
[edit]- Tuberculin, purified protein derivative (PPD)
Sera, immunoglobulins and monoclonal antibodies
[edit]- Anti-rabies virus monoclonal antibodies[note 20]
- Antivenom immunoglobulin[note 153]
- Diphtheria antitoxin
- Equine rabies immunoglobulin
Vaccines
[edit]- BCG vaccine
- Cholera vaccine
- Dengue vaccine
- Diphtheria vaccine
- Ebola vaccine
- Haemophilus influenzae type b vaccine
- Hepatitis A vaccine
- Hepatitis B vaccine
- Hepatitis E vaccine
- Human papilloma virus (HPV) vaccine
- Influenza vaccine (seasonal)
- Japanese encephalitis vaccine
- Malaria vaccine
- Measles vaccine
- Meningococcal meningitis vaccine
- Mpox vaccine
- Mumps vaccine
- Pertussis vaccine
- Pneumococcal vaccine
- Poliomyelitis vaccine
- Rabies vaccine
- Respiratory syncytial virus vaccine
- Rotavirus vaccine
- Rubella vaccine
- Tetanus vaccine
- Tick-borne encephalitis vaccine
- Typhoid vaccine
- Varicella vaccine
- Yellow fever vaccine
Muscle relaxants (peripherally-acting) and cholinesterase inhibitors
[edit]Complementary:
Ophthalmological preparations
[edit]Anti-infective agents
[edit]- Aciclovir
- Azithromycin
- Erythromycin[note 155]
- Gentamicin[note 156]
- Natamycin
- Ofloxacin[note 157]
- Tetracycline[note 158]
Anti-inflammatory agents
[edit]Local anaesthetics
[edit]Miotics and antiglaucoma medicines
[edit]Mydriatics
[edit]Complementary:
- Epinephrine (adrenaline)α
Anti-vascular endothelial growth factor (VEGF) preparations
[edit]Complementary:
Medicines for reproductive health and perinatal care
[edit]Contraceptives
[edit]Oral hormonal contraceptives
[edit]- Ethinylestradiol/levonorgestrel (ethinylestradiol + levonorgestrel)
- Ethinylestradiol/norethisterone (ethinylestradiol + norethisterone)
- Levonorgestrel
- Ulipristal
Injectable hormonal contraceptives
[edit]- Estradiol cypionate/medroxyprogesterone acetate (estradiol cypionate + medroxyprogesterone acetate)
- Medroxyprogesterone acetate
- Norethisterone enantate
Intrauterine devices
[edit]Barrier methods
[edit]Implantable contraceptives
[edit]Intravaginal contraceptives
[edit]Ovulation inducers
[edit]Complementary:
Uterotonics
[edit]Medicines for medical abortion
[edit]- Mifepristone + misoprostol (Co-packaged)
- Misoprostol
Antioxytocics (tocolytics)
[edit]Other medicines administered to the mother
[edit]Medicines administered to the neonate
[edit]Complementary:
- Alprostadil (prostaglandin E1)α[note 167]
- Beractantα
- Ibuprofenα[note 168]
- Poractant alfaα
Peritoneal dialysis solution
[edit]Complementary:
- Intraperitoneal dialysis solution (of appropriate composition in accordance with local clinical guidelines.)α
Medicines for mental and behavioural disorders
[edit]Medicines used in psychotic disorders
[edit]- Fluphenazine[note 169]
- Haloperidol[note 170]
- Olanzapine
- Paliperidone[note 171]
- Risperidone[note 172]
Complementary:
Medicines used in mood disorders
[edit]Medicines used in depressive disorders
[edit]Medicines used in bipolar disorders
[edit]- Carbamazepine
- Lithium carbonate
- Quetiapine[note 174]
- Valproic acid (sodium valproate)[note 19]
Medicines for anxiety disorders
[edit]Medicines used for obsessive compulsive disorders
[edit]Medicines for disorders due to psychoactive substance use
[edit]Medicines for alcohol use disorders
[edit]Medicines for nicotine use disorders
[edit]- Bupropion
- Cytisine (cytisinicline)
- Nicotine replacement therapy (NRT)
- Varenicline
Medicines for opioid use disorders
[edit]Complementary:
Medicines acting on the respiratory tract
[edit]Antiasthmatic medicines and medicines for chronic obstructive pulmonary disease
[edit]- Budesonide[note 178]
- Budesonide/formoterol (budesonide + formoterol)[note 179]
- Epinephrine (adrenaline)
- Ipratropium bromide
- Salbutamol[note 180]
- Tiotropium[note 181]
Solutions correcting water, electrolyte and acid-base disturbances
[edit]Oral
[edit]Parenteral
[edit]- Glucose
- Glucose with sodium chloride
- Potassium chloride
- Sodium chloride
- Sodium hydrogen carbonate
- Sodium lactate, compound solution (Ringer's lactate solution)
Miscellaneous
[edit]Vitamins and minerals
[edit]- Ascorbic acid
- Calcium
- Colecalciferol[note 182]
- Ergocalciferol[note 183]
- Iodine
- Multiple micronutrient powder
- Nicotinamide
- Pyridoxine
- Retinol
- Riboflavin
- Thiamine
Complementary:
Ear, nose and throat medicines
[edit]Medicines for diseases of joints
[edit]Medicines used to treat gout
[edit]Disease-modifying anti-rheumatic drugs (DMARDs)
[edit]Complementary:
Medicines for juvenile joint diseases
[edit]Complementary:
- Acetylsalicylic acid (aspirin)[note 185]
- Adalimumabα[note 81]
- Methotrexateα
- Triamcinolone hexacetonideα[note 186]
Dental medicines and preparations
[edit]- Fluoride
- Glass ionomer cement
- Resin-based composite (low-viscosity)[note 187]
- Resin-based composite (high-viscosity)[note 188]
- Silver diamine fluoride
Notes
[edit]An α indicates the medicine is on the complementary list for which specialized diagnostic or monitoring or training is needed. An item may also be listed as complementary on the basis of higher costs or a less attractive cost-benefit ratio.[4][14]
- ^ Piped nitrous oxide is a major source of atmospheric pollution from healthcare facilities. Point-of-care cylinders are the preferred delivery system over centrally-supplied (piped) delivery systems
- ^ Thiopental is an alternative
- ^ For use in spinal anaesthesia during delivery, to prevent hypotension
- ^ No more than 30% oxygen should be used to initiate resuscitation of neonates less than or equal to 32 weeks of gestation
- ^ Not in children less than three months
- ^ Not recommended for anti‐inflammatory use due to lack of proven benefit to that effect
- ^ For the management of cancer pain
- ^ Hydromorphone and oxycodone are alternatives
- ^ For the management of cancer pain
- ^ a b May be used for buccal administration when solution for oromucosal administration is not available
- ^ a b Dolasetron, granisetron, palonosetron, and tropisetron are alternatives
- ^ Cetirizine and fexofenadine are alternatives
- ^ a b c Prednisone is an alternative
- ^ Alternative formulations of activated charcoal may be used if granules are not available
- ^ For use as adjunctive therapy for treatment-resistant partial or generalized seizures
- ^ Diazepam (injection) and midazolam (injection) are alternatives
- ^ For use in eclampsia and severe pre‐eclampsia and not for other convulsant disorders
- ^ The presence of both 25 mg/5 mL and 30 mg/5 mL strengths on the same market would cause confusion in prescribing and dispensing and should be avoided
- ^ a b c Valproic acid (sodium valproate) is not recommended in women and girls of childbearing potential owing to the high risk of birth defects and neurodevelopmental disorders in children exposed to valproic acid (sodium valproate) in the womb
- ^ a b c d e f g h i j k l m n Including quality-assured biosimilars
- ^ Trihexyphenidyl is an alternative
- ^ Benserazide is an alternative for carbidopa
- ^ Naproxen is an alternative
- ^ The presence of both 120 mg/5 mL and 125 mg/5mL strengths on the same market would cause confusion in prescribing and dispensing and should be avoided
- ^ Eletriptan is an alternative
- ^ Third-generation cephalosporin of choice for use in hospitalized neonates
- ^ a b Do not administer with calcium and avoid in infants with hyperbilirubinemia
- ^ a b > 41 weeks corrected gestational age
- ^ Only for the presumptive treatment of epidemic meningitis in children older than two years
- ^ a b > three months
- ^ a b Oral valaciclovir is an alternative
- ^ Moxidectin is an alternative
- ^ Arpraziquantel is an alternative
- ^ Oxamniquine is listed for use when praziquantel treatment fails
- ^ > one month
- ^ Only for the presumptive treatment of epidemic meningitis in children older than two years and in adults
- ^ Alternatives are 4th level ATC chemical subgroup (J01CF Beta-lactamase resistant penicillins)
- ^ Cloxacillin, dicloxacillin, and flucloxacillin are preferred for oral administration due to better bioavailability
- ^ Use in children <8 years only for life-threatening infections when no alternative exists
- ^ Procaine benzylpenicillin is not recommended as first-line treatment for neonatal sepsis except in settings with high neonatal mortality, when given by trained health workers in cases where hospital care is not achievable
- ^ Third-generation cephalosporin of choice for use in hospitalized neonates
- ^ Erythromycin is an alternative as second choice treatment for pharyngitis in children (EMLc only)
- ^ For use in combination regimens for eradication of H. pylori in adults
- ^ Vancomycin powder for injection may also be used for oral administration
- ^ Imipenem/cilastatin is an alternative for complicated intraabdominal infections and high-risk febrile neutropenia only. Meropenem is the preferred choice for acute bacterial meningitis in neonates
- ^ Tedizolid phosphate is an alternative
- ^ For use only in combination with meropenem or imipenem/cilastatin
- ^ Terizidone is an alternative
- ^ Prothionamide is an alternative for multidrug-resistant tuberculosis
- ^ Imipenem/cilastatin is an alternative
- ^ For treatment of chronic pulmonary aspergillosis, histoplasmosis, sporotrichosis, paracoccidioidomycosis, mycoses caused by T. marneffei and chromoblastomycosis; and prophylaxis of histoplasmosis and infections caused by T. marneffei in AIDS patients
- ^ For treatment of chronic pulmonary aspergillosis and acute invasive aspergillosis
- ^ Anidulafungin and caspofungin are alternatives
- ^ Also indicated for pre-exposure prophylaxis
- ^ > six weeks
- ^ > three years
- ^ ≥ 4 weeks and ≥ 3 kg; ≥ 25 kg
- ^ For use in pregnant women and in second-line regimens in accordance with WHO treatment guidelines
- ^ a b Lamivudine is an alternative for emtricitabine
- ^ Combination also indicated for pre-exposure prophylaxis
- ^ For the treatment of cytomegalovirus retinitis (CMVr)
- ^ For severe illness due to confirmed or suspected influenza virus infection in critically ill hospitalized patients
- ^ For the treatment of cytomegalovirus retinitis (CMVr)
- ^ Pangenotypic when used in combination with sofosbuvir
- ^ Pangenotypic when used in combination with sofosbuvir
- ^ Pangenotypic when used in combination with daclatasvir or ravidasvir
- ^ For the treatment of hepatitis C, in combination with direct acting anti-viral medicines
- ^ Proposed for deletion in 2027
- ^ > 25 kg
- ^ Tinidazole is an alternative
- ^ Liposomal amphotericin B has a better safety profile than the sodium deoxycholate formulation and should be prioritized for selection and use depending on local availability and cost
- ^ a b c For use in the management of severe malaria
- ^ For use only for the treatment of Plasmodium vivax infection
- ^ For use to reduce the transmission of Plasmodium falciparum and for radical cure of Plasmodium vivax and Plasmodium ovale infections
- ^ For use only for prophylaxis of Plasmodium vivax infection
- ^ > 8 years
- ^ For the treatment of 1st and 2nd stage human African trypanosomiasis due to Trypanosoma brucei gambiense infection
- ^ a b To be used for the treatment of Trypanosoma brucei gambiense infection
- ^ To be used for the treatment of the initial phase of Trypanosoma brucei rhodesiense infection
- ^ Only to be used in combination with eflornithine, for the treatment of Trypanosoma brucei gambiense infection
- ^ a b Certolizumab pegol, etanercept, golimumab, and infliximab are alternatives, including quality-assured biosimilars
- ^ Afatinib and gefitinib are alternatives
- ^ Zanubrutinib is an alternative
- ^ As monotherapy for deficient mismatch repair (dMMR ) / microsatellite instability-high (MSI-H) tumours
- ^ Atezolizumab and cemiplimab are alternatives, including quality-assured biosimilars
- ^ Nivolumab is an alternative, including quality-assured biosimilars
- ^ Enzalutamide is an alternative
- ^ Alternatives are 4th level ATC chemical subgroup (L02BG Aromatase inhibitors)
- ^ Flutamide and nilutamide are alternatives
- ^ Goserelin and triptorelin are alternatives
- ^ May also be used for oral administration
- ^ Biscuit or paste of nutritional composition as determined by the UN joint statement on the community-based management of severe acute malnutrition and Codex alimentarius guidelines
- ^ Periconceptual use for prevention of first occurrence of neural tube defects
- ^ Epoetin alfa, beta and theta; darbepoetin alfa; methoxy polyethylene glycol-epoetin beta; and their quality-assured biosimilars are alternatives
- ^ Apixaban, edoxaban, and rivaroxaban are alternatives
- ^ Alternatives are dalteparin and nadroparin, including their quality-assured biosimilars
- ^ Acenocoumarol is an alternative
- ^ a b Deferiprone is an alternative
- ^ Cryoprecipitate (not pathogen-reduced) is an alternative. Native cryoprecipitate should only be used in situations of life-threatening haemorrhage when pathogen-reduced cryoprecipitate is not available
- ^ Polygeline, injectable solution, 3.5% is an alternative
- ^ a b c Carvedilol and metoprolol are alternatives
- ^ Alternatives are 4th level ATC chemical subgroup (C08CA Dihydropyridine derivatives)
- ^ Atenolol, carvedilol, and metoprolol are alternatives. Atenolol should not be used as a first-line agent in uncomplicated hypertension in patients > 60 years
- ^ Alternatives are 4th level ATC chemical subgroup (C09AA ACE inhibitors, plain)
- ^ Hydralazine is listed for use only in the acute management of severe pregnancy-induced hypertension. Its use in the treatment of essential hypertension is not recommended in view of the evidence of greater efficacy and safety of other medicines
- ^ a b c Chlorothiazide, chlorthalidone, and indapamide are alternatives
- ^ Alternatives are 4th level ATC chemical subgroup (C09AA ACE inhibitors, plain) (for lisinopril) and 4th level ATC chemical subgroup (C08CA Dihydropyridine derivatives) (for amlodipine)
- ^ Alternatives are 4th level ATC chemical subgroup (C09AA ACE inhibitors, plain) (for lisinopril) and chlorthalidone, chlorothiazide, indapamide (for hydrochlorothiazide)
- ^ a b Alternatives are 4th level ATC chemical subgroup (C09CA Angiotensin II receptor blockers (ARBs), plain)
- ^ Methyldopa is listed for use only in the management of pregnancy-induced hypertension. Its use in the treatment of essential hypertension is not recommended in view of the evidence of greater efficacy and safety of other medicines
- ^ Alternatives are 4th level ATC chemical subgroup (C09AA ACE inhibitors, plain) (for perindopril); and 4th level ATC chemical subgroup (C08CA Dihydropyridine derivatives) (for amlodipine); and chlorthalidone, chlorothiazide, hydrochlorothiazide (for indapamide)
- ^ Alternatives are 4th level ATC chemical subgroup (C09CA Angiotensin II receptor blockers (ARBs), plain) (for telmisartan); and 4th level ATC chemical subgroup (C08CA Dihydropyridine derivatives) (for amlodipine)
- ^ Alternatives are 4th level ATC chemical subgroup (C09CA Angiotensin II receptor blockers (ARBs), plain) (for telmisartan); and chlorthalidone, chlorothiazide, indapamide (for hydrochlorothiazide)
- ^ Alternatives are 4th level ATC chemical subgroup (C09CA Angiotensin II receptor blockers (ARBs), plain) (for valsartan); 4th level ATC chemical subgroup (C08CA Dihydropyridine derivatives) (for amlodipine); and chlorthalidone, chlorothiazide, indapamide (for hydrochlorothiazide)
- ^ Alternatives are 4th level ATC chemical subgroup (C09AA ACE inhibitors, plain)
- ^ Bumetanide and torasemide are alternatives
- ^ For use in high‐risk patients. Atorvastatin, fluvastatin, lovastatin, and pravastatin are alternatives
- ^ a b Fluvastatin, lovastatin, pravastatin, and simvastatin are alternatives for atorvastatin
- ^ a b 4th level ATC chemical subgroup (C09AA ACE inhibitors, plain) are alternatives for ramipril
- ^ Atorvastatin, fluvastatin, lovastatin, and pravastatin are alternatives for simvastatin
- ^ Bisoprolol, carvedilol, and metoprolol are alternatives for atenolol
- ^ Chlorthalidone, chlorothiazide, and indapamide are alternatives for hydrochlorothiazide
- ^ 4th level ATC chemical subgroup (C09AA ACE inhibitors, plain) are alternatives for perindopril
- ^ 4th level ATC chemical subgroup (C08CA Dihydropyridine derivatives) are alternatives for amlodipine
- ^ Alternatives are 4th level ATC chemical subgroup (D01AC Imidazole and triazole derivatives) excluding combinations
- ^ Alternatives are 4th level ATC chemical subgroup (D07AC Corticosteroids, potent (group III))
- ^ Alternatives are 4th level ATC chemical subgroup (D07AA Corticosteroids, weak (group I))
- ^ Calcitriol and tacalcitol are alternatives
- ^ Podophyllotoxin is an alternative
- ^ Certolizumab pegol, etanercept, infliximab, including quality-assured biosimilars, are alternatives
- ^ Precipitated sulfur topical ointment is an alternative
- ^ Atropine and cyclopentolate are alternatives
- ^ Propanol is an alternative
- ^ Iodine is an alternative
- ^ Alternatives are 4th level ATC chemical subgroup (D08AE Phenol and derivatives)
- ^ Bumetanide and torasemide are alternatives
- ^ Chlorothiazide and chlorthalidone are alternatives
- ^ Alternatives are 4th level ATC chemical subgroup (A02BC Proton pump inhibitors) excluding combinations
- ^ Alternatives are 4th level ATC chemical subgroup (A02BA H2-receptor antagonists) excluding combinations
- ^ Mesalazine is an alternative
- ^ Bisacodyl is an alternative
- ^ In acute diarrhoea zinc sulfate should be used as an adjunct to oral rehydration salts
- ^ Norethisterone is an alternative
- ^ Insulin glargine, Insulin degludec, and insulin detemir, including quality-assured biosimilars, are alternatives
- ^ Insulin lispro, Insulin aspart, and insulin glulisine, including quality-assured biosimilars, are alternatives
- ^ Canagliflozin and dapagliflozin are alternatives
- ^ Glibenclamide not suitable above 60 years. Alternatives are 4th level ATC chemical subgroup (A10BB Sulfonylureas)
- ^ Dulaglutide, liraglutide, and tirzepatide, including quality-assured biosimilars, are alternatives
- ^ a b Carbimazole is an alternative depending on local availability
- ^ For use when alternative first-line treatment is not appropriate or available; and in patients during the first trimester of pregnancy
- ^ For use when alternative first-line treatment is not appropriate or available
- ^ Bromocriptine is an alternative
- ^ Exact type to be defined locally
- ^ Atracurium is an alternative
- ^ For infections due to Chlamydia trachomatis or Neisseria gonorrhoeae
- ^ Amikacin, kanamycin, netilmicin, and tobramycin are alternatives
- ^ Alternatives are 4th level ATC chemical subgroup (S01AE Fluoroquinolones)
- ^ Chlortetracycline and oxytetracycline are alternatives
- ^ Alternatives are 4th level ATC chemical subgroup (S01HA Local anaesthetics) excluding cocaine and combinations
- ^ Carbachol is an alternative
- ^ Alternatives are 4th level ATC chemical subgroup (S01ED Beta blocking agents) excluding combinations
- ^ Cyclopentolate hydrochloride or homatropine hydrobromide are alternatives only for the EMLc
- ^ For use in women actively breastfeeding at least 4 times per day
- ^ Anastrozole is an alternative
- ^ Methylergometrine is an alternative
- ^ Only for use for induction of labour where appropriate facilities are available
- ^ dinoprostone (prostaglandin E2) is an alternative
- ^ Indometacin is an alternative
- ^ Haloperidol decanonate and zuclopenthixol decanonate are alternatives
- ^ Chlorpromazine is an alternative for the tablet
- ^ Risperidone injection is an alternative
- ^ Aripiprazole, olanzapine, paliperidone, and quetiapine are alternatives
- ^ a b c Citalopram, escitalopram, fluvoxamine, paroxetine, and sertraline are alternatives
- ^ Aripiprazole, olanzapine, and paliperidone are alternatives
- ^ Lorazepam is an alternative
- ^ For short-term emergency management of acute and severe anxiety symptoms only
- ^ Buprenorphine is an alternative. The medicines should only be used within an established support programme
- ^ Beclometasone, ciclesonide, flunisolide, fluticasone, and mometasone are alternatives
- ^ Beclometasone/formoterol, budesonide/salmeterol, fluticasone/formoterol, fluticasone furoate/vilanterol, and mometasone/formoterol are alternatives
- ^ Terbutaline is an alternative
- ^ Aclidinium, glycopyrronium, and umeclidinium are alternatives
- ^ Ergocalciferol is an alternative
- ^ Colecalciferol is an alternative
- ^ Ofloxacin is an alternative
- ^ For use for rheumatic fever, juvenile arthritis, Kawasaki disease
- ^ Triamcinolone acetonide is an alternative
- ^ Of any type for use as dental sealant
- ^ Of any type for use as dental filling material
References
[edit]- ^ a b "The WHO Essential Medicines List (EML): 30th anniversary". World Health Organization. Archived from the original on 27 May 2014. Retrieved 26 June 2016.
- ^ a b c d "Essential medicines". World Health Organization. Archived from the original on 2 October 2008. Retrieved 19 January 2017.
- ^ Persaud N, Jiang M, Shaikh R, Bali A, Oronsaye E, Woods H, et al. (June 2019). "Comparison of essential medicines lists in 137 countries". Bull. World Health Organ. 97 (6): 394–404C. doi:10.2471/BLT.18.222448. hdl:10665/325509. ISSN 0042-9686. PMC 6560372. PMID 31210677.
- ^ a b c d e f "19th WHO Model List of Essential Medicines" (PDF). World Health Organization. April 2015. p. Annex 1. Retrieved 17 January 2017.
- ^ a b Bansal D, Purohit VK (January 2013). "Accessibility and use of essential medicines in health care: Current progress and challenges in India". Journal of Pharmacology & Pharmacotherapeutics. 4 (1): 13–18. doi:10.4103/0976-500X.107642. PMC 3643337. PMID 23662019.
- ^ World Health Organization (2003). The selection and use of essential medicines (Report). World Health Organization (WHO). hdl:10665/42826. ISBN 92-4-120920-8. WHO technical report series 920.
- ^ Beall R (2016). "Patents and the WHO Model List of Essential Medicines (18th Edition): Clarifying the Debate on IP and Access" (PDF). World Intellectual Property Organization (WIPO). Retrieved 3 May 2017.
- ^ World Health Organization (1977). The selection of essential drugs: report of a WHO expert committee [meeting held in Geneva from 17 to 21 October 1977]. Geneva: World Health Organization. hdl:10665/41272. ISBN 92-4-120615-2. Technical report series; no. 615.
- ^ Wirtz VJ, Hogerzeil HV, Gray AL, Bigdeli M, de Joncheere CP, Ewen MA, et al. (January 2017). "Essential medicines for universal health coverage". Lancet. 389 (10067): 403–476. doi:10.1016/S0140-6736(16)31599-9. PMC 7159295. PMID 27832874.
- ^ a b c "WHO Model Lists of Essential Medicines". World Health Organization.
The current versions are the 21st WHO Essential Medicines List (EML) and the 7th WHO Essential Medicines List for Children (EMLc) updated in June 2019.
- ^ Prakash B, Nadig P, Nayak A (2016). "Rational Prescription for a Dermatologist". Indian Journal of Dermatology. 61 (1): 32–38. doi:10.4103/0019-5154.174017. PMC 4763692. PMID 26955092.
- ^ a b World Health Organization (2017). WHO model list of essential medicines, 20th list (March 2017, amended August 2017). Geneva. hdl:10665/273826.
{{cite book}}
: CS1 maint: location missing publisher (link) - ^ "Essential Medicines List and WHO Model Formulary". World Health Organization. Archived from the original on 3 August 2008. Retrieved 5 May 2018.
- ^ a b c d World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
{{cite book}}
: CS1 maint: location missing publisher (link) - ^ World Health Organization (2019). Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert Committee on the selection and use of essential medicines. Geneva. hdl:10665/325773. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.
{{cite book}}
: CS1 maint: location missing publisher (link) - ^ "Strengthening access to essential medicines". World Health Organization. Retrieved 3 May 2020.
- ^ a b c d World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ^ a b World Health Organization (2021). Executive summary: the selection and use of essential medicines 2021: report of the 23rd WHO Expert Committee on the selection and use of essential medicines: virtual meeting, 21 June–2 July 2021. Geneva: World Health Organization. hdl:10665/345554. WHO/MHP/HPS/EML/2021.01.
- ^ World Health Organization (2021). The selection and use of essential medicines: report of the WHO Expert Committee on Selection and Use of Essential Medicines, 2021 (including the 22nd WHO model list of essential medicines and the 8th WHO model list of essential medicines for children). Geneva: World Health Organization. hdl:10665/351172. ISBN 978-92-4-004114-1. WHO technical report series;1035. License: CC BY-NC-SA 3.0 IGO.
- ^ World Health Organization (2025). The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. Geneva: World Health Organization. doi:10.2471/B09474. hdl:10665/382243. License: CC BY-NC-SA 3.0 IGO.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines for children: 7th list 2019. Geneva. hdl:10665/325772. WHO/MVP/EMP/IAU/2019.07. License: CC BY-NC-SA 3.0 IGO.
{{cite book}}
: CS1 maint: location missing publisher (link) - ^ World Health Organization (2021). World Health Organization model list of essential medicines for children: 8th list (2021). Geneva: World Health Organization. hdl:10665/345534. WHO/MHP/HPS/EML/2021.03.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex B: World Health Organization model list of essential medicines for children: 9th list (2023). Geneva: World Health Organization. hdl:10665/371091. WHO/MHP/HPS/EML/2023.03.
- ^ a b World Health Organization (2025). The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines for Children,10th list. Geneva: World Health Organization. doi:10.2471/B09475. hdl:10665/382242. License: CC BY-NC-SA 3.0 IGO.
- ^ Rose K, Anker JN (2010). Guide to Paediatric Drug Development and Clinical Research. Karger Medical and Scientific Publishers. p. 42. ISBN 978-3-8055-9362-5.
- ^ Seyberth HW, Rane A, Schwab M (2011). Pediatric Clinical Pharmacology. Springer Science & Business Media. p. 358. ISBN 978-3-642-20195-0.
- ^ Hoppu K (June 2017). "Essential Medicines for Children". Clinical Pharmacology and Therapeutics. 101 (6): 718–720. doi:10.1002/cpt.661. PMID 28182281. S2CID 23873145.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: executive summary of the report of the 24th WHO Expert Committee on Selection and Use of Essential Medicines, 24 28 April 2023. Geneva: World Health Organization. hdl:10665/371291. WHO/MHP/HPS/EML/2023.01.
- ^ World Health Organization (2025). The selection and use of essential medicines 2025: report of the 25th WHO Expert Committee on Selection and Use of Essential Medicines: executive summary. Geneva: World Health Organization. doi:10.2471/B09544. hdl:10665/382350. License: CC BY-NC-SA 3.0 IGO.
Further reading
[edit]- Serafini M, Cargnin S, Massarotti A, Pirali T, Genazzani AA (September 2020). "Essential Medicinal Chemistry of Essential Medicines". Journal of Medicinal Chemistry. 63 (18): 10170–10187. doi:10.1021/acs.jmedchem.0c00415. PMC 8007110. PMID 32352778.
- Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. hdl:10665/44053. ISBN 978-92-4-154765-9.
- The selection and use of essential medicines. Twentieth report of the WHO Expert Committee 2015 (including 19th WHO Model List of Essential Medicines and 5th WHO Model List of Essential Medicines for Children). Geneva: World Health Organization. 2015. hdl:10665/189763. ISBN 978-92-4-069494-1. ISSN 0512-3054. WHO technical report series; no. 994.
- The selection and use of essential medicines: report of the WHO Expert Committee, 2017 (including the 20th WHO Model List of Essential Medicines and the 6th Model List of Essential Medicines for Children). Geneva: World Health Organization. 2017. hdl:10665/259481. ISBN 978-92-4-121015-7. ISSN 0512-3054. WHO technical report series; no. 1006.
- The selection and use of essential medicines: report of the WHO Expert Committee on Selection and Use of Essential Medicines, 2019 (including the 21st WHO Model List of Essential Medicines and the 7th WHO Model List of Essential Medicines for Children). Geneva: World Health Organization. 2019. hdl:10665/330668. ISBN 978-92-4-121030-0. ISSN 0512-3054. WHO technical report series;1021.
- Organization WH (2019). "Additions and deletions of medicines on the WHO model lists of essential medicines: 1977–2017". World Health Organization. hdl:10665/278038. WHO/MVP/EMP/IAU/2019.01.