Protionamide

Protionamide

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	J04AD01 (WHO)
Identifiers
IUPAC name 2-propylpyridine-4-carbothioamide
CAS Number	14222-60-7^Y
PubChem CID	666418
DrugBank	DB12667^Y
ChemSpider	579891^N
UNII	76YOO33643
CompTox Dashboard (EPA)	DTXSID7045940
ECHA InfoCard	100.034.615
Chemical and physical data
Formula	C9H12N2S
Molar mass	180.27 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CCCc1cc(ccn1)C(=S)N
InChI InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)^N Key:VRDIULHPQTYCLN-UHFFFAOYSA-N^N
^NY (what is this?)  (verify)

Protionamide (or prothionamide) is a medication used in the treatment of tuberculosis and leprosy.^[1][2]

Protionamide is a therapeutic alternative on the World Health Organization's List of Essential Medicines.^[3]

References

1. Wang F, Langley R, Gulten G, Dover LG, Besra GS, Jacobs WR, et al. (January 2007). "Mechanism of thioamide drug action against tuberculosis and leprosy". The Journal of Experimental Medicine. 204 (1): 73–8. doi:10.1084/jem.20062100. PMC 2118422. PMID 17227913.
2. Fajardo TT, Guinto RS, Cellona RV, Abalos RM, Dela Cruz EC, Gelber RH (March 2006). "A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy". The American Journal of Tropical Medicine and Hygiene. 74 (3): 457–61. PMID 16525107.
3. World Health Organization (2025). The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. Geneva: World Health Organization. hdl:10665/382243.