This is a list of films which have placed number one at the weekend box office in Venezuela during 2010.
| † | This implies the highest-grossing movie of the year.[1] | 
| # | Date | Film | Gross | Notes | 
| 1 | January 3, 2010 | Avatar | $764,134 |  | 
| 2 | January 10, 2010 | $804,602 |  | 
| 3 | January 17, 2010 | $321,233 |  | 
| 4 | January 24, 2010 | Tooth Fairy | $240,675 |  | 
| 5 | January 31, 2010 | $238,526 |  | 
| 6 | February 7, 2010 | Old Dogs | $273,396 |  | 
| 7 | February 14, 2010 | Percy Jackson & the Olympians: The Lightning Thief | $240,668 |  | 
| 8 | February 21, 2010 | Old Dogs | $234,797 |  | 
| 9 | February 28, 2010 | $220,241 |  | 
| 10 | March 7, 2010 | Alice in Wonderland | $628,604 |  | 
| 11 | March 14, 2010 | $602,006 |  | 
| 12 | March 21, 2010 | $493,098 |  | 
| 13 | March 28, 2010 | $291,301 |  | 
| 14 | April 4, 2010 | How to Train Your Dragon | $271,301 |  | 
| 15 | April 11, 2010 | Date Night | $198,981 |  | 
| 16 | April 18, 2010 | Clash of the Titans | $536,976 |  | 
| 17 | April 25, 2010 | $439,711 |  | 
| 18 | May 2, 2010 | Iron Man 2 | $418,341 |  | 
| 19 | May 9, 2010 | $236,187 |  | 
| 20 | May 16, 2010 | A Nightmare on Elm Street | $270,756 |  | 
| 21 | May 23, 2010 | $254,536 |  | 
| 22 | May 30, 2010 | Marmaduke | $201,269 |  | 
| 23 | June 6, 2010 | Robin Hood | $272,388 |  | 
| 24 | June 13, 2010 | $203,329 |  | 
| 25 | June 20, 2010 | Toy Story 3 | $729,863 |  | 
| 26 | June 27, 2010 | $749,985 |  | 
| 27 | July 4, 2010 | The Twilight Saga: Eclipse | $711,187 |  | 
| 28 | July 11, 2010 | Shrek Forever After | $682,613 |  | 
| 29 | July 18, 2010 | $741,401 |  | 
| 30 | July 25, 2010 | $614,024 |  | 
| 31 | August 1, 2010 | $470,193 |  | 
| 32 | August 8, 2010 | The Karate Kid | $409,123 |  | 
| 33 | August 15, 2010 | Despicable Me | $465,730 |  | 
| 34 | August 22, 2010 | $407,667 |  | 
| 35 | August 29, 2010 | The Last Airbender | $420,004 |  | 
| 36 | September 5, 2010 | The Sorcerer's Apprentice | $465,730 |  | 
| 37 | September 12, 2010 | Resident Evil: Afterlife | $440,431 |  | 
| 38 | September 19, 2010 | $368,845 |  | 
| 39 | September 26, 2010 | $199,699 |  | 
| 40 | October 3, 2010 | Legend of the Guardians: The Owls of Ga'Hoole | $332,234 |  | 
| 41 | October 10, 2010 | $281,138 |  | 
| 42 | October 17, 2010 | $194,044 |  | 
| 43 | October 24, 2010 | La Hora Cero | $174,838 |  | 
| 44 | October 31, 2010 | Saw 3D | $250,576 |  | 
| 45 | November 7, 2010 | Paranormal Activity 2 | $197,020 |  | 
| 46 | November 14, 2010 | Life as We Know It | $179,213 |  | 
| 47 | November 21, 2010 | Harry Potter and the Deathly Hallows – Part 1 | $940,949 | Harry Potter and the Deathly Hallows  – Part 1 had the highest weekend debut of 2010. | 
| 48 | November 28, 2010 | Tangled † | $687,730 |  | 
| 49 | December 5, 2010 | $718,219 |  | 
| 50 | December 12, 2010 | Megamind | $455,096 |  | 
| 51 | December 19, 2010 | Tron: Legacy | $465,499 |  | 
| 52 | December 26, 2010 | $348,980 |  | 
| 53 | January 2, 2011 | Tron: Legacy | $225,720 |  | 
Highest-grossing films
[edit]
Highest-grossing films of 2010 in Venezuela[1]
| Rank | Title | Studio | Domestic Gross | 
| 1. | Tangled | Walt Disney Pictures | $6,863,748 | 
| 2. | Toy Story 3 | Walt Disney Pictures / Pixar Animation Studios | $6,339,322 | 
| 3. | Shrek Forever After | Paramount Pictures / DreamWorks Animation | $5,984,037 | 
| 4. | Harry Potter and the Deathly Hallows – Part 1 | Warner Bros. / Heyday Films | $4,743,014 | 
| 5. | Alice in Wonderland | Walt Disney Pictures | $4,335,113 | 
| 6. | La Hora Cero | Centro Nacional Autónomo de Cinematografía | $3,947,360 | 
| 7. | Tron: Legacy | Walt Disney Pictures | $3,419,740 | 
| 8. | The Twilight Saga: Eclipse | Summit Entertainment | $3,220,661 | 
| 9. | Clash of the Titans | Warner Bros. | $3,010,415 | 
| 10. | The Karate Kid | Columbia Pictures | $2,638,033 | 
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