GPR160

GPR160
Identifiers
Aliases	GPR160, GPCR1, GPCR150, G protein-coupled receptor 160
External IDs	MGI: 1919112; HomoloGene: 8659; GeneCards: GPR160; OMA:GPR160 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.2 Start 170,037,995 bp[1] End 170,085,392 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 A3 Start 30,910,099 bp[2] End 30,951,341 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of sigmoid colon rectum corpus epididymis duodenum bone marrow jejunal mucosa bone marrow cell mucosa of transverse colon trabecular bone Top expressed in spermatocyte spermatid seminiferous tubule lens jejunum epithelium of lens right kidney granulocyte duodenum skin of abdomen More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane receptor complex membrane plasma membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26996 71862 Ensembl ENSG00000173890 ENSMUSG00000037661 UniProt Q9UJ42 Q3U3F9 RefSeq (mRNA) NM_014373 NM_001134385 NM_001134386 NM_001286994 NM_001286995 NM_001286996 NM_027965 NM_001357144 RefSeq (protein) NP_055188 NP_001127857 NP_001127858 NP_001273923 NP_001273924 NP_001273925 NP_082241 NP_001344073 Location (UCSC) Chr 3: 170.04 – 170.09 Mb Chr 3: 30.91 – 30.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 160 is a protein that in humans is encoded by the GPR160 gene.^[5][6] It has been shown to be important in embryonic stem cell development, is involved in the perception of neuropathic pain, and is present in elevated levels in some cancers.^{[7][8][9][10]} GPR160 has been suggested as the receptor for Cocaine- and amphetamine-regulated transcript, also known as CART.^{[11][12][13][14]} However other research has since shown that it does not appear CART binds to GPR160 directly.^[15][16] This suggests that an as yet unidentified target for CART may modulate GPR160 mediated responses indirectly under certain conditions, but without directly binding to the GPR160 receptor.

References

1. GRCh38: Ensembl release 89: ENSG00000173890 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037661 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. Bibcode:2002FEBSL.520...97T. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
6. "Entrez Gene: GPR160 G protein-coupled receptor 160".
7. Abbas A, Jun P, Yuan JY, Sun L, Jiang J, Yuan S (2022). "Downregulation of GPR160 inhibits the progression of glioma through suppressing epithelial to mesenchymal transition (EMT) biomarkers". Basic & Clinical Pharmacology & Toxicology. 131 (4): 241–250. doi:10.1111/bcpt.13769. PMID 35771163.
8. Owe-Larsson M, Pawłasek J, Piecha T, Sztokfisz-Ignasiak A, Pater M, Janiuk IR (2023). "The Role of Cocaine- and Amphetamine-Regulated Transcript (CART) in Cancer: A Systematic Review". International Journal of Molecular Sciences. 24 (12): 9986. doi:10.3390/ijms24129986. PMC 10297965. PMID 37373130.
9. Fan S, Guo C, Yang G, Hong L, Li H, Ma J, et al. (2024). "GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway". Journal of Genetics and Genomics. 51 (10): 1055–1065. doi:10.1016/j.jgg.2024.05.003. PMID 38750952.
10. Xu C, Wang Y, Ni C, Xu M, Yin C, He Q, et al. (2024). "Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent models". EMBO Reports. 25 (12): 5429–5455. doi:10.1038/s44319-024-00292-6. PMC 11624276. PMID 39448865.
11. Yosten GL, Harada CM, Haddock C, Giancotti LA, Kolar GR, Patel R, et al. (May 2020). "GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents". The Journal of Clinical Investigation. 130 (5): 2587–2592. doi:10.1172/JCI133270. PMC 7190928. PMID 31999650.
12. Sanchez-Navarro MJ, Borner T, Reiner BC, Crist RC, Samson WK, Yosten GL, et al. (2023). "GPR-160 Receptor Signaling in the Dorsal Vagal Complex of Male Rats Modulates Meal Microstructure and CART-Mediated Hypophagia". Nutrients. 15 (10): 2268. doi:10.3390/nu15102268. PMC 10221706. PMID 37242151.
13. Schafer RM, Giancotti LA, Davis DJ, Larrea IG, Farr SA, Salvemini D (2024). "Behavioral characterization of G-protein-coupled receptor 160 knockout mice". Pain. 165 (6): 1361–1371. doi:10.1097/j.pain.0000000000003136. PMC 11090760. PMID 38198232.
14. Schafer RM, Giancotti LA, Chrivia JC, Li Y, Mufti F, Kufer TA, et al. (2025). "CARTp/GPR160 mediates behavioral hypersensitivities in mice through NOD2". Pain. 166 (4): 902–915. doi:10.1097/j.pain.0000000000003418. PMID 39356206.
15. Freitas-Lima LC, Pačesová A, Staňurová J, Šácha P, Marek A, Hubálek M, et al. (2023). "GPR160 is not a receptor of anorexigenic cocaine- and amphetamine-regulated transcript peptide". European Journal of Pharmacology. 949 175713. doi:10.1016/j.ejphar.2023.175713. PMID 37054941.
16. Ye C, Zhou Q, Lin S, Yang W, Cai X, Mai Y, et al. (2024). "High expression of GPR160 in prostate cancer is unrelated to CARTp-mediated signaling pathways". Acta Pharmaceutica Sinica B. 14 (3): 1467–1471. doi:10.1016/j.apsb.2023.11.025. PMC 10935005. PMID 38487007.

Further reading

• Conklin D, Yee DP, Millar R, Engelbrecht J, Vissing H (February 2000). "Mining of assembled expressed sequence tag (EST) data for protein families: application to the G protein-coupled receptor superfamily". Briefings in Bioinformatics. 1 (1): 93–99. doi:10.1093/bib/1.1.93. PMID 11466977.