Draft:Vipergen
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Submission declined on 3 September 2025 by RangersRus (talk).
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Vipergen
[edit]Vipergen (Vipergen ApS) is a privately-held Danish biotechnology company headquartered in Copenhagen, Denmark. Vipergen specializes in small-molecule drug discovery based on next-generation DNA-encoded library (DEL) technologies.[1] Founded in 2005 by Dr Nils Jakob Vest Hansen and currently employs 16.[2][3]
History
[edit]Vipergen was founded in Copenhagen in 2005 and remains privately owned by CEO Dr Nils Hansen, together with chairman Gunnar Kjems. Early work focused on developing DEL synthesis utilizing the so called YoctoReactor[4][5]. In recent years the firm subsequently introduced new technologies for the screening of DNA-Encoded Libraries.[6][7][8][9][10]
Today, Vipergen operates as a fee-for-service DEL screening provider,[11] by forming partnerships with other pharmaceutical companies.[12][13][14][15]
See also
[edit]- DNA-Encoded Libraries
- Drug Discovery
- Medicinal Chemistry
- High-Throughput Screening
- Fragment Based Drug Discovery
References
[edit]- ^ Gironda-Martínez, Adrián; Donckele, Etienne J.; Samain, Florent; Neri, Dario (2021-08-13). "DNA-Encoded Chemical Libraries: A Comprehensive Review with Succesful Stories and Future Challenges". ACS Pharmacology & Translational Science. 4 (4): 1265–1279. doi:10.1021/acsptsci.1c00118. PMC 8369695. PMID 34423264.
- ^ "Who is Vipergen? Read all about us and drug discovery here". vipergen. Retrieved 2025-08-08.
- ^ Holt, Mette (2006-09-15). "Nystartede Vipergen endte med private investorer | Ingeniøren". ing.dk (in Danish). Retrieved 2025-09-03.
- ^ Hansen, Margit Haahr; Blakskjær, Peter; Petersen, Lars Kolster; Hansen, Tara Heitner; Højfeldt, Jonas Westergaard; Gothelf, Kurt Vesterager; Hansen, Nils Jakob Vest (2009-01-28). "A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution". Journal of the American Chemical Society. 131 (3): 1322–1327. Bibcode:2009JAChS.131.1322H. doi:10.1021/ja808558a. ISSN 0002-7863. PMID 19123795.
- ^ Blakskjaer, Peter; Heitner, Tara; Hansen, Nils Jakob Vest (2015-06-01). "Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery". Current Opinion in Chemical Biology. Next generation therapeutics. 26: 62–71. doi:10.1016/j.cbpa.2015.02.003. ISSN 1367-5931. PMID 25732963.
- ^ Petersen, L. K.; Blakskjær, P.; Chaikuad, A.; Christensen, A. B.; Dietvorst, J.; Holmkvist, J.; Knapp, S.; Kořínek, M.; Larsen, L. K.; Pedersen, A. E.; Röhm, S.; Sløk, F. A.; Hansen, N. J. V. (2016-07-12). "Novel p38α MAP kinase inhibitors identified from yoctoReactor DNA-encoded small molecule library". MedChemComm. 7 (7): 1332–1339. doi:10.1039/C6MD00241B. ISSN 2040-2511.
- ^ Petersen, Lars K.; Christensen, Allan B.; Andersen, Jacob; Folkesson, Charlotta G.; Kristensen, Ole; Andersen, Charlotte; Alzu, Amaya; Sløk, Frank A.; Blakskjær, Peter; Madsen, Daniel; Azevedo, Carlos; Micco, Iolanda; Hansen, Nils J. V. (2021-02-24). "Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell". Journal of the American Chemical Society. 143 (7): 2751–2756. Bibcode:2021JAChS.143.2751P. doi:10.1021/jacs.0c09213. ISSN 0002-7863. PMID 33577316.
- ^ April 2023, Tom Cohen | 19. "How DEL Screening is Used in Living Cells". oxfordglobal.com. Retrieved 2025-09-10.
{{cite web}}: CS1 maint: numeric names: authors list (link) - ^ Huang, Yiran; Li, Xiaoyu (2021). "Recent Advances on the Selection Methods of DNA-Encoded Libraries". ChemBioChem. 22 (14): 2384–2397. doi:10.1002/cbic.202100144. ISSN 1439-7633. PMID 33891355.
- ^ Satz, Alexander L.; Brunschweiger, Andreas; Flanagan, Mark E.; Gloger, Andreas; Hansen, Nils J. V.; Kuai, Letian; Kunig, Verena B. K.; Lu, Xiaojie; Madsen, Daniel; Marcaurelle, Lisa A.; Mulrooney, Carol; O’Donovan, Gary; Sakata, Sylvia; Scheuermann, Jörg (2022-01-17). "DNA-encoded chemical libraries". Nature Reviews Methods Primers. 2 (1): 3. doi:10.1038/s43586-021-00084-5. ISSN 2662-8449.
- ^ "Drug Discovery Services - Get an early lead". vipergen. Retrieved 2025-08-08.
- ^ "Leo Pharma indgår partnerskab med Vipergen". medwatch.dk (in Danish). 2022-06-16. Retrieved 2025-08-12.
- ^ Vipergen. "Vipergen Establishes Research Partnership with ALK Focused on DNA-Encoded Library (DEL)-Based Drug Discovery for Allergy Immunotherapies". www.prnewswire.com (Press release). Retrieved 2025-08-22.
- ^ "Joint News Release - BASF and Vipergen accelerate targeted research and development of sustainable crop protection products". www.basf.com. Retrieved 2025-09-03.
- ^ Vipergen. "Vipergen Establishes DNA Encoded Library (DEL)-Based Drug Discovery Partnership with Theseus Pharmaceuticals Focused on Targeted Cancer Therapies". www.prnewswire.com (Press release). Retrieved 2025-08-12.
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