Draft:Mindstate Design Labs




Mindstate Design Labs

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Mindstate Design Labs
Company typePrivate
IndustryBiotechnology
Founded2021
FoundersDillan DiNardo, Thomas Ray
Headquarters
San Francisco
,
United States
Websitewww.mindstate.design

Mindstate Design Labs is an American biotechnology company that develops psychoactive pharmacotherapies. The company has developed an artificial intelligence platform to map molecular targets against psychoactive effects and its lead program is MSD-001, a serotonergic agonist being investigated in early-stage clinical research.[1][2][3][4][5][6]

History

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Mindstate Design Labs was founded in 2021 by Dillan DiNardo and Thomas S. Ray and participated in Y Combinator’s Summer 2021 batch.[5][7]

In February 2022, the company announced an $11.5 million seed round led by Initialized Capital with participation from Metaplanet Holdings, Day One Ventures, K50 Ventures, and angels including Max Hodak, Naval Ravikant, Justin Kan, Apoorva Mehta, and Fred Ehrsam.[2][5][8][9][10]

In September 2024, the company announced regulatory clearance from the United States and European Union to begin a Phase I study of MSD-001.[1][11]

Technology and product development

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Mindstate’s research program uses an artificial-intelligence platform, Osmanthus, to analyze language from human experience reports and integrate biochemical and pharmacological data in an effort to identify relationships between molecular targets and specific mental states.[4][12][13][14][15][16][17]

The company’s lead program, MSD-001 (a formulation of 5-MeO-MiPT), is being developed as a neutral psychoactive base intended for combination with other agents chosen on the basis of insights from Osmanthus.[4][6][11]

References

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  1. ^ a b Ovalle, David; Beard, McKenzie (September 5, 2024). "FDA gives an early nod to psychedelic research". The Washington Post. Retrieved August 16, 2025.
  2. ^ a b Lee, Yeji Jesse (February 10, 2022). "A Y Combinator startup that's creating a new class of psychedelics just raised $11.5 million from big Silicon Valley investors". Business Insider. Retrieved August 16, 2025.
  3. ^ Bayer, Max (March 13, 2024). "After crunching 70k 'trip reports', Mindstate looks to test first AI-derived psychedelic on humans". Fierce Biotech.
  4. ^ a b c Dimitropoulos, Stav (June 12, 2025). "Scientists Have a Powerful New Tool in Consciousness Research—And Even Help You Reach Transcendence". Popular Mechanics. Retrieved August 16, 2025.
  5. ^ a b c Sullivan, Mark (February 12, 2022). "VC money keeps flowing into psychedelics-based mental health". Fast Company. Retrieved August 16, 2025.
  6. ^ a b Ducharme, Jamie (October 2, 2024). "Safer Psychedelic Drugs May Be Coming". Time. Retrieved August 16, 2025.
  7. ^ Wilhelm, Alex; Mascarenhas, Natasha; Coldewey, Devin; Matney, Lucas; Kumparak, Greg (September 1, 2021). "Here are all the companies from Day 2 of Y Combinator's Summer 2021 Demo Day". TechCrunch. Retrieved August 16, 2025.
  8. ^ "VC Health Pulse: Startup Led by Brett Giroir Targets Antiviral Drugs; Jo Viney Lands $101 Million for Seismic Therapeutic; Superhuman". The Wall Street Journal. February 10, 2022. Retrieved August 16, 2025.
  9. ^ Brodwin, Erin (February 11, 2022). "Psychedelic startup Mindstate's $11.5M trip". Axios. Retrieved August 16, 2025.
  10. ^ Lee, Yeji Jesse; Schuster-Bruce, Catherine (March 29, 2022). "Here are the 7 hottest psychedelics startups that are set to take off in 2022, according to 3 top VCs in the space". Business Insider. Retrieved August 16, 2025.
  11. ^ a b Meissen, Andrew (September 20, 2024). "Mindstate Uses AI to Design "Next-Gen" Psychedelics Combined With 5-MeO-MiPT". Lucid News. Retrieved August 16, 2025.
  12. ^ "Transforming Psychedelics into Approved Medicines". Genetic Engineering & Biotechnology News. October 6, 2022. Retrieved August 16, 2025.
  13. ^ Kary, Tiffany (August 22, 2022). "Are Hallucinogen Look-Alikes Illegal? DEA Delay Creates Limbo". Bloomberg. Retrieved August 16, 2025.
  14. ^ Meisel, Chelsea (October 12, 2022). "The Future of Psychedelic Medicine Will Be Drugs You've Never Heard Of". Vice. Retrieved August 16, 2025.
  15. ^ Schneider, Helena Bottemiller (July 18, 2023). "The Psychedelic AI Found". Politico. Retrieved August 16, 2025.
  16. ^ Love, Shayla (October 20, 2024). "Tripping on Nothing". The Atlantic. Retrieved August 16, 2025.
  17. ^ Nichols, Megan Ray (June 20, 2025). "The next era of psychedelics may be precision-designed". Big Think. Retrieved August 16, 2025.