2C-B-PYR

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2C-B-PYR
Clinical data
Other names2C-B-Pyr; β,N-Dimethylene-2C-B; 3-(4-Bromo-2,5-dimethoxyphenyl)pyrrolidine
Drug classSerotonin 5-HT2A and 5-HT2C receptor agonist
ATC code
  • None
Identifiers
  • 3-(4-bromo-2,5-dimethoxyphenyl)pyrrolidine
PubChem CID
ChemSpider
Chemical and physical data
FormulaC12H16BrNO2
Molar mass286.169 g·mol−1
3D model (JSmol)
  • COC1=CC(=C(C=C1C2CCNC2)OC)Br
  • InChI=1S/C12H16BrNO2/c1-15-11-6-10(13)12(16-2)5-9(11)8-3-4-14-7-8/h5-6,8,14H,3-4,7H2,1-2H3
  • Key:BSXIERMNSJEFOE-UHFFFAOYSA-N

2C-B-PYR, also known as 3-(4-bromo-2,5-dimethoxyphenyl)pyrrolidine, is a serotonin receptor modulator of the phenethylamine family.[1] It is a cyclized phenethylamine, more specifically a cyclized pyrrolidine derivative of the psychedelic drug 2C-B, and is closely related to ZC-B (azetidine) and LPH-5 (piperidine).[1] The drug acts as a potent and efficacious agonist of the serotonin 5-HT2A and 5-HT2C receptors.[1] It was patented by Lophora in 2021 and was first described in the scientific literature in 2024.[2][1]

See also

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References

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  1. ^ a b c d M RoRsted E, Jensen AA, Smits G, Frydenvang K, Kristensen JL (May 2024). "Discovery and Structure-Activity Relationships of 2,5-Dimethoxyphenylpiperidines as Selective Serotonin 5-HT2A Receptor Agonists". Journal of Medicinal Chemistry. 67 (9): 7224–7244. doi:10.1021/acs.jmedchem.4c00082. PMC 11089506. PMID 38648420.
  2. ^ US 20210137908A1, Kristensen JL, Jensen AA, Märcher-Rørsted E, Leth-Petersen S, "5-ht2a agonists for use in treatment of depression", published 15 February 2022, assigned to Lophora ApS 
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