Talk:Samuel Refetoff

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The Wikimedia Foundation's Terms of Use require that editors disclose their "employer, client, and affiliation" with respect to any paid contribution; see WP:PAID. For advice about reviewing paid contributions, see WP:COIRESPONSE. HRShami (talk · contribs) has been paid by Samuel Refetoff.

Reference fix.

This edit request by an editor with a conflict of interest was declined.

The following references need to be fixed.

• Reference number 3: ^[1]

• Reference 4: ^[2]

• Reference 5: ^[3]

• Please change the line Refetoff is known for discovering resistance to thyroid hormone (RTH) to Refetoff discovered resistance to thyroid hormone. So that it aligns with NPOV.

• Please remove this line to align with NPOV: His scholarly contributions include publications in journals such as Endocrine Reviews, The Journal of Clinical Endocrinology & Metabolism, Nature Genetics, and Journal of Clinical Investigation Thyroid

HRShami (talk) HRShami (talk) 07:24, 8 May 2025 (UTC)[reply]

 Not done: You can do a archivebot, if I understand correctly its just a minor error, it should be fixed, by a bot if not, please reply to me! Valorrr ^{(lets chat)} 16:28, 21 May 2025 (UTC)[reply]

Hello Valorrr. I tried using archivebot, but it does not work for fixing citation. Also, I have requested two other edits as well that cannot be done through a bot. HRShami (talk) 09:33, 26 May 2025 (UTC)[reply]

 Note: Marking for another editor. Valorrr ^{(lets chat)} 16:42, 26 May 2025 (UTC)[reply]

Changing sources in research section to secondary.

This edit request by an editor with a conflict of interest has now been answered.

In due course, I have understood that as a paid editor I should refrain from using primary sources in the research section, which is one of the reasons for the tag at the top. Therefore, I have changed the resources with secondary resources in the research section in this edit request. I have also removed lines that were not supported by secondary sources in this section. Please change the current research section with the text below.

Refetoff has worked in endocrinology, with research interests in congenital and genetic defects affecting thyroid hormone synthesis, transport, and action. Together with DeWind and DeGroot, he characterized a familial syndrome linking deaf-mutism, stippled epiphyses, goiter, and elevated PBI.^[4]

Refetoff identified mutations in proteins that transport thyroid hormone in blood, namely thyroxine-binding globulin (TBG)^[5] and albumin, causing familial dysalbuminemic hyperthyroxinemia.^[6] He identified mutations in the gene NKX2.1 that encodes TTF1, resulting in thyroid, brain and lung abnormalities.^[7] His laboratory uncovered mutations of the SLC16A2 gene, encoding the thyroid hormone cell membrane transporter MCT8, which cause severe thyroid hormone deprivation in the brain, resulting in psychoneuromotor abnormalities formerly described by Allan, Herndon, and Dudley.^[8] Along with A.M. Dumitrescu and others, he documented that mutations in the SECISBP2 gene disrupted selenoprotein synthesis, impairing thyroid hormone metabolism.^[9] HRShami (talk) 04:56, 18 June 2025 (UTC)[reply]

 Done Likeanechointheforest (talk) 17:29, 27 June 2025 (UTC)[reply]

Updating Awards

The user below has a request that an edit be made to Samuel Refetoff. That user has an actual or apparent conflict of interest. The requested edits backlog is high. Please be very patient. There are currently 187 requests waiting for review. Please read the instructions for the parameters used by this template for accepting and declining them, and review the request below and make the edit if it is well sourced, neutral, and follows other Wikipedia guidelines and policies.

In order to align with NPOV and verifiability, I have removed minor awards and awards that could not be verified from the awarding body's website. Please change the current list of awards with the list below.

• 1991 – Paul Starr Award and Lectureship, The American Thyroid Association^[10]
• 1996 – Sidney H. Ingbar Distinguished Lectureship Award, The American Thyroid Association^[11]
• 2004 – Honorary Fellow, Royal College of Physicians of Ireland^[12]
• 2005 – John B. Stanbury Thyroid Pathophysiology Medal, The American Thyroid Association^[13]
• 2012 – Fred Conrad Koch Medal, Endocrine Society^[14]
• 2013 – Honorary Member, European Thyroid Association^[15]
• 2019 – The Lissitzky Medal, European Thyroid Association^[16]

HRShami (talk) 05:09, 18 June 2025 (UTC)[reply]

 Done Likeanechointheforest (talk) 17:27, 27 June 2025 (UTC)[reply]

Updating lead section

The user below has a request that an edit be made to Samuel Refetoff. That user has an actual or apparent conflict of interest. The requested edits backlog is high. Please be very patient. There are currently 187 requests waiting for review. Please read the instructions for the parameters used by this template for accepting and declining them, and review the request below and make the edit if it is well sourced, neutral, and follows other Wikipedia guidelines and policies.

In this edit request, I am removing some extra information from the lead section. I am also removing primary sources and replacing it with a secondary source.

Samuel Refetoff is a Bulgarian-American endocrinologist and an academic. He is the Frederick H. Rawson Professor in Medicine and director of the Endocrinology Laboratories at The University of Chicago.^[17]

Refetoff is known for discovering resistance to thyroid hormone (RTH), also known as Refetoff syndrome and its genetic and molecular basis, along with resistance to thyrotropin (RTSH) and a hereditary thyroid hormone metabolism defect caused by SECISBP2 gene mutations.^[18]

Refetoff has received awards, including the Rosalind Pitt-Rivers Award from the British Thyroid Foundation,^[19] the Stanbury Pathophysiology Medal from the American Thyroid Association,^[20] and the Fred Conrad Koch Medal from the Endocrine Society.^[21] HRShami (talk) 05:22, 30 June 2025 (UTC)[reply]

1. Sakurai, A.; Takeda, K.; Ain, K.; Ceccarelli, P.; Nakai, A.; Seino, S.; Bell, G. I.; Refetoff, S.; DeGroot, L. J. (November 1989). "Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta". Proceedings of the National Academy of Sciences of the United States of America. 86 (22): 8977–8981. doi:10.1073/pnas.86.22.8977. ISSN 0027-8424.
2. Sunthornthepvarakul, Thongkum; Gottschalk, Michael E.; Hayashi, Yoshitaka; Refetoff, Samuel (19 January 1995). "Resistance to Thyrotropin Caused by Mutations in the Thyrotropin-Receptor Gene". New England Journal of Medicine. 332 (3): 155–160. doi:10.1056/NEJM199501193320305. ISSN 0028-4793.
3. Dumitrescu, Alexandra M.; Liao, Xiao-Hui; Abdullah, Mohamed S. Y.; Lado-Abeal, Joaquin; Majed, Fathia Abdul; Moeller, Lars C.; Boran, Gerard; Schomburg, Lutz; Weiss, Roy E.; Refetoff, Samuel (November 2005). "Mutations in SECISBP2 result in abnormal thyroid hormone metabolism". Nature Genetics. 37 (11): 1247–1252. doi:10.1038/ng1654. ISSN 1061-4036.
4. Gershengorn, M C; Weintraub, B D (1 September 1975). "Thyrotropin-induced hyperthyroidism caused by selective pituitary resistance to thyroid hormone. A new syndrome of "inappropriate secretion of TSH"". Journal of Clinical Investigation. 56 (3): 633–642. doi:10.1172/JCI108133.
5. Parad, R B; Kramer, J; Strunk, R C; Rosen, F S; Davis, A E (September 1990). "Dysfunctional C1 inhibitor Ta: deletion of Lys-251 results in acquisition of an N-glycosylation site". Proceedings of the National Academy of Sciences. 87 (17): 6786–6790. doi:10.1073/pnas.87.17.6786.
6. Dieu, Xavier; Bouzamondo, Nathalie; Briet, Claire; Illouz, Frédéric; Moal, Valérie; Boux de Casson, Florence; Bouhours-Nouet, Natacha; Reynier, Pascal; Coutant, Régis; Rodien, Patrice; Mirebeau-Prunier, Delphine (3 July 2020). "Familial Dysalbuminemic Hyperthyroxinemia: An Underdiagnosed Entity". Journal of Clinical Medicine. 9 (7): 2105. doi:10.3390/jcm9072105.
7. Nettore, Immacolata Cristina; Mirra, Paola; Ferrara, Alfonso Massimiliano; Sibilio, Annarita; Pagliara, Valentina; Kay, Claudia Suemi Kamoi; Lorenzoni, Paulo Josè; Werneck, Lineu Cesar; Bruck, Isac; dos Santos, Lucia Helena Coutinho; Beguinot, Francesco; Salvatore, Domenico; Ungaro, Paola; Fenzi, Gianfranco; Scola, Rosana Herminia; Macchia, Paolo Emidio (June 2013). "Identification and Functional Characterization of a Novel Mutation in the NKX2-1 Gene: Comparison with the Data in the Literature". Thyroid. 23 (6): 675–682. doi:10.1089/thy.2012.0267.
8. Lin, Peng; Liu, Huituan; Lou, Jiwu; Lyu, Guizhen; Li, Yanwei; He, Peiqing; Fu, Youqing; Zhang, Ronghua; Zhang, Yuqiong; Yan, Tizhen (23 April 2025). "Novel SLC16A2 Frameshift Mutation as a Cause of Allan-Herndon-Dudley Syndrome and its Implications for Carrier Screening". Pharmacogenomics and Personalized Medicine. 18: 85–94. doi:10.2147/PGPM.S492647.
9. Schoenmakers, Erik; Chatterjee, Krishna (1 September 2020). "Human Disorders Affecting the Selenocysteine Incorporation Pathway Cause Systemic Selenoprotein Deficiency". Antioxidants & Redox Signaling. 33 (7): 481–497. doi:10.1089/ars.2020.8097.
10. "Paul Starr Award Lecture". American Thyroid Association. Retrieved 2025-06-18.
11. "Sidney H. Ingbar Distinguished Lectureship Award". American Thyroid Association. Retrieved 2025-04-23.
12. "Accolades go to faculty, clinical staff in biological sciences". UChicago News. Retrieved 2025-04-23.
13. "John B. Stanbury Thyroid Pathophysiology Medal". American Thyroid Association. Retrieved 2025-06-18.
14. "THE ENDOCRINE SOCIETY 2012 LAUREATE AWARDS". Molecular Endocrinology. 26 (8): 1468–1480. 1 August 2012. doi:10.1210/mend.26.8.zmg1468. ISSN 0888-8809.
15. "Honorary Members – European Thyroid Association". European Thyroid Association. Retrieved 2025-04-23.
16. "ETA prize winners 2019". European Thyroid Association. Retrieved 2025-04-23.
17. "SAMUEL REFETOFF, MD Interview conducted by Michael Chappelle" (PDF). endocrine.org. Retrieved 2025-04-23.
18. Bianco, Antonio (May 2025). "Fifty Years of Support From the NIDDK for a Pioneer in Thyroid Research". Endocrinology,. 166 (5). doi:10.1210/endocr/bqaf060. Retrieved 30 June 2025.
19. "The Pitt-Rivers and George Murray lectures". British Thyroid Association. Retrieved 2025-04-23.
20. "John B. Stanbury Thyroid Pathophysiology Medal". American Thyroid Association. Retrieved 2025-04-23.
21. "Past Laureate Award Recipients". Endocrine Society. 28 September 2022. Retrieved 2025-04-23.