Talk:Modafinil

This is the talk page for discussing improvements to the Modafinil article. This is not a forum for general discussion of the subject of the article.

Put new text under old text. Click here to start a new topic. New to Wikipedia? Welcome! Learn to edit; get help. Assume good faith Be polite and avoid personal attacks Be welcoming to newcomers Seek dispute resolution if needed Article policies Neutral point of view No original research Verifiability

Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL

Archives: Index, 1, 2Auto-archiving period: 6 months

Modafinil is currently a Biology and medicine good article nominee. Nominated by Maxim Masiutin (talk) at 21:24, 23 December 2024 (UTC) Any editor who has not nominated or contributed significantly to this article may review it according to the good article criteria to decide whether or not to list it as a good article. To start the review process, click start review and save the page. (See here for the good article instructions.) Short description: Eugeroic medication

Modafinil was nominated as a Natural sciences good article, but it did not meet the good article criteria at the time (February 13, 2024, reviewed version). There are suggestions on the review page for improving the article. If you can improve it, please do; it may then be renominated.

This article is rated B-class on Wikipedia's content assessment scale. It is of interest to the following WikiProjects:

Pharmacology High‑importance This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks. High This article has been rated as High-importance on the project's importance scale. Medicine Mid‑importance Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine. Mid This article has been rated as Mid-importance on the project's importance scale. Neuroscience Mid‑importance This article is within the scope of WikiProject Neuroscience, a collaborative effort to improve the coverage of Neuroscience on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks. Mid This article has been rated as Mid-importance on the project's importance scale. Transhumanism Low‑importance Modafinil' is part of WikiProject Transhumanism, which aims to organize, expand, clean up, and guide Transhumanism related articles on Wikipedia. If you would like to participate, you can edit this article, or visit the project page for more details. Low This article has been rated as Low-importance on the project's importance scale. For more information and how you can help click Show: If you would like to participate, you can edit this article, or visit the project page for more details. Quick help: Main talk page Article layout Links to Transhumanism information and Wikipedia:Research resources Writing about religion and Article development Citing sources, Verifying sources and Original research Assume good faith and be civil See changes to: Core articles Transhumanism article New Transhumanism articles To Do List: edit - history - watch - purge Join WikiProject transhumanism and be bold Show off a userbox with {{userWPA}} or {{userWPA2}} and attract potential members Help with articles. See this month's adopt an article. Help out with the To-do lists Be consistent Use a "standard" layout for transhumanism related articles (see: The perfect article, and Featured articles) Add Transhumanism navigation template on the bottom of all transhumanism articles; (use {{Transhumanism}} or see navigation template) Add Transhumanism info box to all transhumanism related talk pages (use {{Wpa}} or see info box) Add [[Category:transhumanism]] to the bottom of all transhumanism related articles, so it shows up on the list of transhumanism articles Maintenance / Etc Find/cite sources for all positions of an article (see citing sources. Try to expand stubs, however, some "new" articles may be neologisms, as this is common with positions on theories on life and may be suitable for deletion (see deletion process) Watch the list of transhumanism related articles and add to accordingly (see transhumanism articles) And always write for an encyclopedia. Create Notable transhumanist articles Shorten / merge into others Expand a transhumanism stub Your immediate attention false choice into false dilemma - discuss whether you are for or against this merge here Clarify references in Transhumanism, using footnotes. Psychoactive and Recreational Drugs (defunct) This article is within the scope of WikiProject Psychoactive and Recreational Drugs, a project which is currently considered to be defunct.

This article has been mentioned by a media organization: "Wikipedia: Meet the men and women who write the articles". BBC. 2012-07-14. Archived from the original on 2012-08-22. Retrieved 2012-08-22.

Statistical Significance

I refer to the statement “ Modafinil has been shown to have minor and barely statistically significant effectiveness in managing fatigue in people with MS”; in basic statistical analysis where a p value is predetermined by the researcher to account for the probability that their results are unlikely due to chance, the results can either be “statistically significant “ or not. Even if the p value generated is very close to the the predetermined probability value, this has no meaning whatsoever, because we’re working with probability values or p values based on a normal curve. The error in this article is find sometimes in other scholarly articles I read or asked to review for blind peer reviewed journals; which is something like “ the results where almost statistically significant “ or “ the results approach statistical significance “. These statements are also examples of misinterpretation and or misunderstanding of parametric statistics.

Therefore I strongly recommend that the article be updated to improve scholarly rigour. If no one has raises an objection or needs clarification, or makes the amendment, I will undertake to do this myself.

Dr.khatmando (talk) 14:04, 10 May 2025 (UTC) Dr. Jason M Dixon Advanced psychometrics, epidemiology, clinical educator. Editorial Board, WikiJournal of Medicine[reply]

Yes, that sentence and its paragraph were poorly written and sourced, and were removed with 3 edits in Special:Diff/1289788786. Zefr (talk) 21:24, 10 May 2025 (UTC)[reply]

Good oh! After looking at the cited references, and the results, discussion of these related to MS, did not add value to the article itself.

Your edits make for a better read. Thanks for your attention to the matter. Cheers Dr. J Dr.khatmando (talk) 21:43, 10 May 2025 (UTC)[reply]

Special:Diff/1289787389 shows the removal; Special:Diff/1289788786 doesn't.

I don't agree that there's anything inherently wrong with the "the results approach statistical significance" or "barely statistically significant effectiveness" language.

I say that "because we’re working with probability values or p values based on a normal curve" is not a compelling argument.

I object to the removal on that basis.

The "often report" language is certainly not compatible with scholarly rigor. Flagging / Removing. Looking at the widely used review, cite_note-pmid38988104-42, the effectiveness in managing fatigue in PWMS is poor and it directly contradicts the unsourced "without causing drowsiness or disrupting nighttime sleep" claim in the paragraph. Flagging / Removing. Figures 1-5 (all the forest plots) show that across all metrics, most of the individual studies did not find statistically significant effectiveness in managing fatigue in PWMS. Many of the results favored control over Modafonil. RememberOrwell (talk) 21:57, 24 August 2025 (UTC)[reply]