Talk:Leprosy

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Treatment available in Romania

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The statement ”Although the forced quarantine or segregation of patients is unnecessary in places where adequate treatments are available, many leper colonies still remain around the world in countries such as” is incorrect for Romania and, I suspect, for a number of the other listed countries as well. The people who still live in Tichilești (the former leper colony in Romania) only do so now because, having lived with leprosy for so long before treatment was available, don't have anything left outside that community. The problem is lack of social integration; the statement implies that leprosy treatment is unavailable in Romania and that patients are unnecessarily isolated, which is false.

http://www.esquire.ro/articole/reportaje/inapoi-la-tichilesti.htm
http://adevarul.ro/news/societate/reportajIn-leprozerie-nu-alege-1_50c614c6596d720091e2d970/index.html
http://www.9am.ro/stiri-revista-presei/Social/19126/Leprozeria-de-la-Tichilesti-cea-mai-deschisa-lume-inchisa.html

— Preceding unsigned comment added by 79.119.99.124 (talk • contribs)

Clarification request

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This part of the first paragraph is a little unclear to me:

Contrary to folklore, leprosy does not cause body parts to fall off, although they can become numb or diseased as a result of secondary infections; these occur as a result of the body's defenses being compromised by the primary disease.[4][5] Secondary infections, in turn, can result in tissue loss causing fingers and toes to become shortened and deformed, as cartilage is absorbed into the body.[4][5][6]

The article is accompanied by photographs of people with stumps where their fingers should be. This seems to confirm the basic idea of the folklore: that leprosy causes its victims to lose parts of their fingers. So how precisely is the folklore incorrect? Is it that the fingers do not "fall off", they shrink? Or is it that the "tissue loss" is not caused by the primary disease?

Currently it reads like the result of several rounds of quibling editing. Could someone with more understanding of the topic please rewrite so as to make it more precise, more informative, and less argumentative?

Chappell (talk) 19 August 2013

(cut from) Signs and symptoms

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This is all very interesting (below) but doesn't list the symptoms. It lists a single external sign; but nothing about what the patient experiences during early onset, established disease and later symptoms. This is a very poor article in this regard. (posted by User:Stonelaughter)

United States

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Lists symptoms of infection rather than United States specific information, which are not cited and differing from the original symptoms section and endemic area section. First paragraph should be integrated into more appropriate section and symptoms if true moved to proper section.— Preceding unsigned comment added by Sjwmcguire (talk • contribs) 02:23, November 25, 2014‎ (UTC)

Treatment

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“A three-drug regimen of rifampicin, dapsone, and clofazimine is recommended for all people with leprosy, for six months for paucibacillary leprosy and 12 months for multibacillary leprosy". followed by, “The molecular mechanisms involved in the interaction between rifampicin and dapsone have been elucidated". [1] Uchika (talk) 15:53, 13 February 2025 (UTC)[reply]

I assume you meant to preface this post with something like:
  • I would to propose the following sentence and reference to be added to the article in the "Treatment" section:
I think it would make more sense to summarize the review. The sentence does not help readers. Since I know there is an COI issue I will try to make a summary. Johnjbarton (talk) 17:13, 13 February 2025 (UTC)[reply]

References

  1. ^ George, J. (2020). "Metabolism and interactions of antileprosy drugs" (PDF). Biochemical Pharmacology. 177 (July): 113993. doi:10.1016/j.bcp.2020.113993. PMID 32339493.{{cite journal}}: CS1 maint: article number as page number (link)

Ref added to second sentence of Treatment without any need for additional text, as the existing text described three-drug regimen and durations. David notMD (talk) 17:11, 13 February 2025 (UTC)[reply]

Ok I added a paragraph based on the review and moved the ref to that paragraph. Please check. Johnjbarton (talk) 19:59, 13 February 2025 (UTC)[reply]