TC-O 9311

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TC-O 9311
Identifiers
  • 1-[(3,5-dimethoxybenzoyl)amino]-3-naphthalen-1-ylurea
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC20H19N3O4
Molar mass365.389 g·mol−1
3D model (JSmol)
  • COC1=CC(=CC(=C1)C(=O)NNC(=O)NC2=CC=CC3=CC=CC=C32)OC
  • InChI=1S/C20H19N3O4/c1-26-15-10-14(11-16(12-15)27-2)19(24)22-23-20(25)21-18-9-5-7-13-6-3-4-8-17(13)18/h3-12H,1-2H3,(H,22,24)(H2,21,23,25)
  • Key:KPTMSQHTGZMEFU-UHFFFAOYSA-N

TC-O 9311 is a chemical compound which acts as a small-molecule agonist of the previously orphan receptor GPR139.[1] It has been used to investigate the structure and function of the GPR139 receptor, and its interactions with other receptors with which it is co-expressed in the body such as the dopamine D2 receptor and the melanocortin receptors.[2][3][4]

References

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  1. ^ Dvorak CA, Coate H, Nepomuceno D, Wennerholm M, Kuei C, Lord B, et al. (September 2015). "Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor". ACS Medicinal Chemistry Letters. 6 (9): 1015–1018. doi:10.1021/acsmedchemlett.5b00247. PMC 4569879. PMID 26396690.
  2. ^ Nepomuceno D, Kuei C, Dvorak C, Lovenberg T, Liu C, Bonaventure P (2018). "Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 in Vitro". Frontiers in Pharmacology. 9 157. doi:10.3389/fphar.2018.00157. PMC 5863515. PMID 29599718.
  3. ^ Wang L, Lee G, Shih A, Kuei C, Nepomuceno D, Wennerholm M, et al. (February 2019). "Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors". Pharmacology Research & Perspectives. 7 (1) e00466. doi:10.1002/prp2.466. PMC 6367278. PMID 30774960.
  4. ^ Wang L, Lee G, Kuei C, Yao X, Harrington A, Bonaventure P, et al. (2019). "GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact". Frontiers in Neuroscience. 13 281. doi:10.3389/fnins.2019.00281. PMC 6443882. PMID 30971885.