RPS6KA5

RPS6KA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VZO, 3KN5, 3KN6
Identifiers
Aliases	RPS6KA5, MSK1, MSPK1, RLPK, ribosomal protein S6 kinase A5
External IDs	OMIM: 603607; MGI: 1920336; HomoloGene: 48302; GeneCards: RPS6KA5; OMA:RPS6KA5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.11 Start 90,847,861 bp[1] End 91,060,641 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 100,514,698 bp[2] End 100,693,242 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tail of epididymis nipple corpus callosum inferior ganglion of vagus nerve buccal mucosa cell Brodmann area 23 Pons bronchial epithelial cell Skeletal muscle tissue of biceps brachii Top expressed in dorsal striatum zygote olfactory tubercle secondary oocyte lobe of cerebellum cerebellar vermis nucleus accumbens gastrula subiculum primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding metal ion binding kinase activity protein binding ATP binding magnesium ion binding protein serine/threonine kinase activity Cellular component cytoplasm nucleoplasm nucleus Biological process intracellular signal transduction regulation of transcription, DNA-templated epidermal growth factor receptor signaling pathway phosphorylation stimulatory C-type lectin receptor signaling pathway axon guidance positive regulation of histone acetylation interleukin-1-mediated signaling pathway protein phosphorylation positive regulation of CREB transcription factor activity positive regulation of NF-kappaB transcription factor activity inflammatory response negative regulation of transcription, DNA-templated negative regulation of cytokine production positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9252 73086 Ensembl ENSG00000100784 ENSMUSG00000021180 UniProt O75582 Q8C050 RefSeq (mRNA) NM_004755 NM_182398 NM_001322227 NM_001322228 NM_001322229 NM_001322230 NM_001322231 NM_001322232 NM_001322233 NM_001322234 NM_001322235 NM_001322236 NM_001322237 NM_001322238 NM_153587 NM_001330702 RefSeq (protein) NP_001309156 NP_001309157 NP_001309158 NP_001309159 NP_001309160 NP_001309161 NP_001309162 NP_001309163 NP_001309164 NP_001309165 NP_001309166 NP_001309167 NP_004746 NP_872198 NP_001317631 NP_705815 Location (UCSC) Chr 14: 90.85 – 91.06 Mb Chr 12: 100.51 – 100.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene.^[5][6][7] This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.^[8][9]

Interactions

RPS6KA5 has been shown to interact with CREB1.^[5][10]

References

1. GRCh38: Ensembl release 89: ENSG00000100784 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021180 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". The EMBO Journal. 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
6. Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 87 (3–4): 261–262. doi:10.1159/000015441. PMID 10702687. S2CID 10527498.
7. "Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5".
8. Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, et al. (2003-06-02). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". The EMBO Journal. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. ISSN 0261-4189. PMC 156769. PMID 12773393.
9. Reul JM, Chandramohan Y (2007-08-01). "Epigenetic mechanisms in stress-related memory formation". Psychoneuroendocrinology. Integrative approaches to neural plasticity (Lille Summer School, 2006). 32 Suppl 1: S21 – S25. doi:10.1016/j.psyneuen.2007.03.016. ISSN 0306-4530. PMID 17644269. S2CID 24217924.
10. Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase". The EMBO Journal. 20 (16): 4370–4379. doi:10.1093/emboj/20.16.4370. ISSN 0261-4189. PMC 125559. PMID 11500364.

Further reading

• Chung J, Uchida E, Grammer TC, Blenis J (Nov 1997). "STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation". Molecular and Cellular Biology. 17 (11): 6508–6516. doi:10.1128/MCB.17.11.6508. PMC 232504. PMID 9343414.
• Jain N, Zhang T, Fong SL, Lim CP, Cao X (Dec 1998). "Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)". Oncogene. 17 (24): 3157–3167. doi:10.1038/sj.onc.1202238. PMID 9872331.
• New L, Zhao M, Li Y, Bassett WW, Feng Y, Ludwig S, et al. (Jan 1999). "Cloning and characterization of RLPK, a novel RSK-related protein kinase". Journal of Biological Chemistry. 274 (2): 1026–1032. doi:10.1074/jbc.274.2.1026. PMID 9873047.
• Thomson S, Clayton AL, Hazzalin CA, Rose S, Barratt MJ, Mahadevan LC (Sep 1999). "The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase". The EMBO Journal. 18 (17): 4779–4793. doi:10.1093/emboj/18.17.4779. PMC 1171550. PMID 10469656.
• Lim CP, Cao X (Oct 1999). "Serine phosphorylation and negative regulation of Stat3 by JNK". Journal of Biological Chemistry. 274 (43): 31055–31061. doi:10.1074/jbc.274.43.31055. PMID 10521505.
• Buck M, Poli V, Geer P, Chojkier M, Hunter T (Dec 1999). "Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha". Molecular Cell. 4 (6): 1087–1092. doi:10.1016/S1097-2765(00)80237-3. PMID 10635333.
• Lizcano JM, Morrice N, Cohen P (Jul 2000). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155". The Biochemical Journal. 349 (Pt 2): 547–557. doi:10.1042/0264-6021:3490547. PMC 1221178. PMID 10880354.
• Hefner Y, Borsch-Haubold AG, Murakami M, Wilde JI, Pasquet S, Schieltz D, et al. (Dec 2000). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases". Journal of Biological Chemistry. 275 (48): 37542–37551. doi:10.1074/jbc.M003395200. PMID 10978317.
• Arthur JS, Cohen P (Sep 2000). "MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells". FEBS Letters. 482 (1–2): 44–48. doi:10.1016/S0014-5793(00)02031-7. PMID 11018520.
• Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, et al. (Jun 2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth". Journal of Biological Chemistry. 276 (22): 19469–19482. doi:10.1074/jbc.M009953200. PMID 11297520.
• Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S, Williams BR (May 2001). "Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3". The EMBO Journal. 20 (10): 2487–2496. doi:10.1093/emboj/20.10.2487. PMC 125453. PMID 11350938.
• Liu G, Zhang Y, Bode AM, Ma WY, Dong Z (Mar 2002). "Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation". Journal of Biological Chemistry. 277 (11): 8810–8816. doi:10.1074/jbc.M110477200. PMID 11777913.
• Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JS (Apr 2002). "MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts". Molecular and Cellular Biology. 22 (8): 2871–2881. doi:10.1128/MCB.22.8.2871-2881.2002. PMC 133730. PMID 11909979.
• Markou T, Lazou A (Aug 2002). "Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase". The Biochemical Journal. 365 (Pt 3): 757–763. doi:10.1042/BJ20011828. PMC 1222733. PMID 11994045.
• Toska K, Kleppe R, Armstrong CG, Morrice NA, Cohen P, Haavik J (Nov 2002). "Regulation of tyrosine hydroxylase by stress-activated protein kinases". Journal of Neurochemistry. 83 (4): 775–783. doi:10.1046/j.1471-4159.2002.01172.x. PMID 12421349.
• Janknecht R (Feb 2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)". Oncogene. 22 (5): 746–755. doi:10.1038/sj.onc.1206185. PMID 12569367. S2CID 30183941.
• Dolled-Filhart M, Camp RL, Kowalski DP, Smith BL, Rimm DL (Feb 2003). "Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis". Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 9 (2): 594–600. PMID 12576423.