Q-type calcium channel
| calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CACNA1A | ||||||
| Alt. symbols | CACNL1A4, SCA6, MHP1, MHP | ||||||
| IUPHAR | 532 | ||||||
| NCBI gene | 773 | ||||||
| HGNC | 1388 | ||||||
| OMIM | 601011 | ||||||
| RefSeq | NM_000068 | ||||||
| UniProt | O00555 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13 | ||||||
| |||||||
The Q-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
They are poorly understood, but like R-type calcium channels, they appear to be present in cerebellar granule cells. They have a high threshold of activation and relatively slow kinetics.
Mutations in the CACNA1A gene that encodes this protein are responsible for familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6).[1]
References
[edit]- ^ Indelicato E, Unterberger I, Nachbauer W, Eigentler A, Amprosi M, Zeiner F, et al. (July 2021). "The electrophysiological footprint of CACNA1A disorders". Journal of Neurology. 268 (7): 2493–2505. doi:10.1007/s00415-021-10415-x. PMC 8217028. PMID 33544220.
External links
[edit]- Q-Type+Calcium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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