Propofol hemisuccinate

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Propofol hemisuccinate
Identifiers
  • 4-[2,6-di(propan-2-yl)phenoxy]-4-oxobutanoic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
Chemical and physical data
FormulaC16H22O4
Molar mass278.348 g·mol−1
3D model (JSmol)
  • CC(C)C1=C(C(=CC=C1)C(C)C)OC(=O)CCC(=O)O
  • InChI=1S/C16H22O4/c1-10(2)12-6-5-7-13(11(3)4)16(12)20-15(19)9-8-14(17)18/h5-7,10-11H,8-9H2,1-4H3,(H,17,18)
  • Key:ORMHJJCIJXWHFH-UHFFFAOYSA-N

Propofol hemisuccinate, is an anesthetic drug which is an ester substituted prodrug of propofol. Propofol itself is a viscous, oily liquid which does not dissolve in water and has to be formulated as an oil-in-water emulsion. Propofol hemisuccinate is a modified form of propofol which can be made into a water-soluble salt, and can be administered by routes such as by inhalation which are impossible with the unmodified propofol parent compound. It has improved neuroprotective properties compared to propofol.[1][2][3]

See also

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References

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  1. ^ Sagara Y, Hendler S, Khoh-Reiter S, Gillenwater G, Carlo D, Schubert D, et al. (December 1999). "Propofol hemisuccinate protects neuronal cells from oxidative injury". Journal of Neurochemistry. 73 (6): 2524–2530. doi:10.1046/j.1471-4159.1999.0732524.x. PMID 10582614.
  2. ^ Vansant G, Trauger RJ, Cameron A, Vendemelio M, Kreitschitz S, Carlo AT, et al. (May 2007). "Propofol hemisuccinate suppression of experimental autoimmune encephalomyelitis". Autoimmunity. 40 (3): 180–186. doi:10.1080/08916930701204467. PMID 17453716.
  3. ^ Dhir A, Zolkowska D, Murphy RB, Rogawski MA (January 2011). "Seizure protection by intrapulmonary delivery of propofol hemisuccinate". The Journal of Pharmacology and Experimental Therapeutics. 336 (1): 215–222. doi:10.1124/jpet.110.173591. PMID 20837991.


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