Povl Krogsgaard-Larsen

  1. Home
  2. Wiki
Povl Krogsgaard-Larsen
Born (1941-05-17) May 17, 1941 (age 84)
Frøslev, Denmark
Alma materRoyal Danish School of Pharmacy, Copenhagen[1]
OccupationMedicinal chemist
Years active1972–present
OrganizationUniversity of Copenhagen
Known forAMPA; THIP; Others
Websitehttps://drug.ku.dk/staff/?pure=en/persons/94758
https://researchprofiles.ku.dk/en/persons/povl-krogsgaard-larsen

Povl Krogsgaard-Larsen (born May 17, 1941) is a Danish medicinal chemist who studies the glutamatergic, GABAergic, and cholinergic neurotransmitter systems and drugs acting on these systems.[2][3][4][5][6][1] He is known for discovering and developing the AMPA receptor agonist AMPA and the Amanita muscaria- or muscimol-derived GABAA receptor agonist THIP (gaboxadol), among many other scientific contributions.[3][2][4][5][6] Some other notable drugs he has developed include the GABAA receptor agonist isoguvacine and the GABA reuptake inhibitors nipecotic acid and guvacine (which led to the subsequent independent development of tiagabine).[6] Krogsgaard-Larsen has published more than 400 scientific papers and has edited 8 books.[1] He is considered to be a giant in the field of medicinal chemistry and to be the most impactful Danish medicinal chemist.[2] An autobiography was published for Krogsgaard-Larsen in 2011.[2]

Selected publications

[edit]
  • Krogsgaard-Larsen P, Johnston GA (December 1975). "Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds". J Neurochem. 25 (6): 797–802. doi:10.1111/j.1471-4159.1975.tb04410.x. PMID 1206398.
  • Krogsgaard-Larsen P, Johnston GA, Curtis DR, Game CJ, McCulloch RM (December 1975). "Structure and biological activity of a series of conformationally restricted analogues of GABA". J Neurochem. 25 (6): 803–809. doi:10.1111/j.1471-4159.1975.tb04411.x. PMID 1206399.
  • Krogsgaard-Larsen P, Johnston GA, Lodge D, Curtis DR (July 1977). "A new class of GABA agonist". Nature. 268 (5615): 53–55. doi:10.1038/268053a0. PMID 196200.
  • Krogsgaard-Larsen P, Honoré T, Hansen JJ, Curtis DR, Lodge D (March 1980). "New class of glutamate agonist structurally related to ibotenic acid". Nature. 284 (5751): 64–66. doi:10.1038/284064a0. PMID 6101908.
  • Honoré T, Lauridsen J, Krogsgaard-Larsen P (January 1982). "The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes". J Neurochem. 38 (1): 173–178. doi:10.1111/j.1471-4159.1982.tb10868.x. PMID 6125564.
  • Bräuner-Osborne H, Egebjerg J, Nielsen EO, Madsen U, Krogsgaard-Larsen P (July 2000). "Ligands for glutamate receptors: design and therapeutic prospects". J Med Chem. 43 (14): 2609–2645. doi:10.1021/jm000007r. PMID 10893301.
  • Jensen AA, Frølund B, Liljefors T, Krogsgaard-Larsen P (July 2005). "Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations". J Med Chem. 48 (15): 4705–4745. doi:10.1021/jm040219e. PMID 16033252.
  • Demmer CS, Krogsgaard-Larsen N, Bunch L (December 2011). "Review on modern advances of chemical methods for the introduction of a phosphonic acid group". Chem Rev. 111 (12): 7981–8006. doi:10.1021/cr2002646. PMID 22010799.
  • Stromgaard, K.; Krogsgaard-Larsen, P.; Madsen, U. (2022). Textbook of Drug Design and Discovery (5 ed.). Taylor & Francis Limited (Sales). ISBN 978-1-032-33994-8. Retrieved 10 February 2025.

References

[edit]
  1. ^ a b c Krogsgaard-Larsen P, Frølund B, Liljefors T (2002). "Specific GABA(A) agonists and partial agonists". Chem Rec. 2 (6): 419–430. doi:10.1002/tcr.10040. PMID 12469353. [Povl] Krogsgaard-Larsen was born on the island of Mors, Denmark in 1941. He graduated from the Royal Danish School of Pharmacy, Copenhagen, in 1967. The Ph.D. and D.Sc. degrees were acquired at the Royal Danish School of Pharmacy in 1970 and 1980, respectively. He was appointed research professor in 1986 and full professor in 1991 in medicinal chemistry at this school. He obtained honorary doctor degrees from Louis Pasteur University, Strasbourg, France, in 1992 and from Uppsala University, Sweden, in 2000. He has received a large number of research awards and prizes, including The H.C. Ørsted Award (1967), The Ole Rømer Research Award (1983), The Lundbeck Foundation Prize (1989), The Paul Ehrlich Prize, France (1989), and The W. Th. Nauta Award, The Netherlands (1996). He is the European Editor of the Journal of Medicinal Chemistry, and has since 2001 been the Rector at The Royal Danish School of Pharmacy. He is a member of The Royal Danish Academy of Sciences and Letters, The Danish Academy of Natural Sciences, and The Danish Academy of Technical Sciences and is a member of the boards of The Carlsberg Foundation and The Alfred Benzon Foundation. He is Chairman of the Board of the Carlsberg Laboratory and the graduate school, Drug Research Academy. He has been director of the research centers PharmaBiotec (1987–1999) and NeuroScience PharmaBiotec (1997–2001). He has been doing pioneering research in design of specific ligands for GABA and glutamate receptors and transport mechanisms and has designed and developed series of specific muscarinic and nicotinic acetylcholine receptor ligands. He is author and co-author of 400 research papers and review articles, and he has edited 8 books. The textbook "Drug Design and Discovery" 3rd Edition (Eds. P. Krogsgaard-Larsen, Ulf Madsen and Tommy Liljefors) was published in June 2002.
  2. ^ a b c d Bøgesø KP (October 2014). "Povl Krogsgaard-Larsen: a giant in medicinal chemistry research". Neurochem Res. 39 (10): 1847–1849. doi:10.1007/s11064-014-1437-5. PMID 25227749.
  3. ^ a b Bräuner-Osborne, Hans; Schousboe, Arne (2014). "Introduction to Special Issue in Honor of Professor Povl Krogsgaard-Larsen". Neurochemical Research. 39 (10): 1845–1846. doi:10.1007/s11064-014-1408-x. ISSN 0364-3190.
  4. ^ a b Morris, Hamilton (18 June 2021). "Gaboxadol, by Hamilton Morris". Harper's Magazine. Retrieved 10 February 2025.
  5. ^ a b Hamilton Morris (25 December 2021). "PODCAST 36: An Amanita Christmas with Dr. Povl Krogsgaard-Larsen". The Hamilton Morris Podcast (Podcast). Patreon. Retrieved 10 February 2025.
  6. ^ a b c "Povl Krogsgaard-Larsen". University of Copenhagen Research Portal. 14 February 2013. Retrieved 10 February 2025.