PSB-KD107

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PSB-KD107
Identifiers
  • 9-[2-(1H-indol-3-yl)ethyl]-1,3-dimethyl-7,8-dihydro-6H-purino[7,8-a]pyrimidine-2,4-dione
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
Chemical and physical data
FormulaC20H22N6O2
Molar mass378.436 g·mol−1
3D model (JSmol)
  • CN1C2=C(C(=O)N(C1=O)C)N3CCCN(C3=N2)CCC4=CNC5=CC=CC=C54
  • InChI=1S/C20H22N6O2/c1-23-17-16(18(27)24(2)20(23)28)26-10-5-9-25(19(26)22-17)11-8-13-12-21-15-7-4-3-6-14(13)15/h3-4,6-7,12,21H,5,8-11H2,1-2H3
  • Key:PUJKERUFRDZALE-UHFFFAOYSA-N

PSB-KD107 is an experimental drug that acts as a potent and selective agonist for the cannabinoid-like NAGly receptor, also known as GPR18. It has antiinflammatory effects, and has been studied in an animal model of Duchenne muscular dystrophy.[1][2]

References

[edit]
  1. ^ Schoeder CT, Mahardhika AB, Drabczyńska A, Kieć-Kononowicz K, Müller CE (October 2020). "Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18". ACS Medicinal Chemistry Letters. 11 (10): 2024–2031. doi:10.1021/acsmedchemlett.0c00208. PMC 7549263. PMID 33062188.
  2. ^ Dort J, Orfi Z, Fiscaletti M, Campeau PM, Dumont NA (2023). "Gpr18 agonist dampens inflammation, enhances myogenesis, and restores muscle function in models of Duchenne muscular dystrophy". Frontiers in Cell and Developmental Biology. 11: 1187253. doi:10.3389/fcell.2023.1187253. PMC 10461444. PMID 37645248.
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