New methylene blue

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New methylene blue
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.026.833 Edit this at Wikidata
UNII
  • InChI=1S/C18H22N3S.ClH/c1-5-19-13-9-17-15(7-11(13)3)21-16-8-12(4)14(20-6-2)10-18(16)22-17;/h7-10,19-20H,5-6H2,1-4H3;1H/q+1;/p-1 checkY
    Key: NZYCYASKVWSANA-UHFFFAOYSA-M checkY
  • InChI=1/C18H22N3S.ClH/c1-5-19-13-9-17-15(7-11(13)3)21-16-8-12(4)14(20-6-2)10-18(16)22-17;/h7-10,19-20H,5-6H2,1-4H3;1H/q+1;/p-1
    Key: NZYCYASKVWSANA-REWHXWOFAR
  • [Cl-].Cc1cc2nc3cc(C)c(cc3[s+]c2cc1NCC)NCC
Properties
C18H22N3S:SCl ZnCl2
Molar mass 484.22 g/mol
Melting point 239 °C (462 °F; 512 K)
Boiling point Decomposes
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H302, H312, H332
P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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New methylene blue (also NMB, and Basic Blue 24) is an organic compound of the thiazine class of heterocycles. It is used as a stain and as an antimicrobial agent. It is classified as an azine dye, and the chromophore is a cation, the anion is often unspecified.[1]

New Methylene Blue contains the word "New" in its name to differentiate the effectiveness of staining, between it's predecessor methylene blue, the chemical structure of methylene blue, and the colors between the two.[2]

Applications

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NMB is a staining agent used in diagnostic cytopathology and histopathology, typically for staining immature red blood cells. It is a supravital stain.[3] It is closely related to methylene blue, an older stain in wide use.


Safety

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New methylene blue is toxic. Skin contact or inhalation should be avoided.

See also

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References

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  1. ^ Vennerstrom, Jonathan L.; Makler, Michael T.; Angerhofer, Cidy K.; Williams, Jean A. "Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazine" Antimicrobial Agents and Chemotherapy (1995), 39(12), 2671–7. doi:10.1128/AAC.39.12.2671.
  2. ^ "New Methylene Blue as A Reticulocyte Stain". George Brecher. 1 Sep 1949.
  3. ^ "Reticulocyte Count" (PDF). Prentice-Hall.