Mycobacterium obuense
| Mycobacterium obuense | |
|---|---|
Scientific classification 
| |
| Domain: | Bacteria |
| Kingdom: | Bacillati |
| Phylum: | Actinomycetota |
| Class: | Actinomycetes |
| Order: | Mycobacteriales |
| Family: | Mycobacteriaceae |
| Genus: | Mycobacterium |
| Species: | M. obuense
|
| Binomial name | |
| Mycobacterium obuense (ex Tsukamura and Mizuno 1971) Tsukamura and Mizuno 1981
| |
Mycobacterium obuense is a species of soil-dwelling scotochromogenic Mycobacterium.[1] The cell wall of M. obuense contains 1-tetradecanol, 2-octadecanol, and 2-eicosanol,[2] and triacylated lipoproteins.
Use in immunomodulatory therapy
[edit]Preparations of heat-killed Mycobacterium obuense (such as IMM-101) are immunomodulatory and have been used to direct the immune response in the treatment of cancers—notably pancreatic cancer and melanoma. Recent trials have been directed towards the treatment of colorectal cancer.[3] It has been shown that human myeloid dendritic cells, (antigen-presenting cells that serve as a bridge linking the adaptive and innate immune system), can detect mycobacterial triacylated lipoproteins via TLR2 and TLR1.[4]
References
[edit]- ^ Tsukamura, M; Mizuno, S (October 1971). "Mycobacterium obuense, a rapidly growing scotochromogenic mycobacterium capable of forming a black product from p-aminosalicylate and salicylate". J. Gen. Microbiol. 68 (2): 129–34. doi:10.1099/00221287-68-2-129. PMID 5136244.
- ^ P.L. Valero-Guillén, F. Martín-Luengo (1986). "1-Tetradecanol, a new alcohol found in the cell wall of some rapidly growing chromogenic mycobacteria". FEMS Microbiology Letters. 35: 59–63. doi:10.1111/j.1574-6968.1986.tb01499.x.
- ^ "Clinical trials - new cancer treatment". Thelondonclinic.co.uk. 2012-04-25. Archived from the original on 2012-09-20. Retrieved 2012-10-04.
- ^ S. Bazzi, H. Modjtahedi, S. Mudan, M. Achkar, C., G.M. Bahr (2017). "Immunomodulatory effects of heat-killed Mycobacterium obuense on human blood dendritic cells". Innate Immunity. 23 (7): 592–605. doi:10.1177/1753425917727838. PMID 28853313. S2CID 206788250.
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External links
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