Michaelis–Gutmann bodies

Micrograph showing Michaelis-Gutmann bodies. H&E stain.

Michaelis–Gutmann bodies (M–G bodies) are concentrically layered basophilic inclusions found in Hansemann cells in the urinary tract. These are 2 to 10 μm in diameter, and are thought to represent remnants of phagosomes mineralized by iron and calcium deposits.^{[citation needed]}

M–G bodies are a pathognomonic feature of malakoplakia, an inflammatory condition that affects the genitourinary tract. They were initially discovered in 1902 by Leonor Michaelis and Carl Gutmann.^{[citation needed]}

Michaelis–Gutmann bodies stain positive for von kossa (calcium), Prussian Blue (iron), and PAS diastase stain.

References

• University of Chicago; Emerging Infections
• Who Named It? M–G bodies
• "Malakoplakia". www.pathologyoutlines.com. Retrieved 2025-10-02.