Methylvanillylecgonine

Methylvanillylecgonine

Names
IUPAC name Methyl 3β-[(3-hydroxy-4-methoxybenzoyl)oxy]tropane-2β-carboxylate
Systematic IUPAC name Methyl (1R,2R,3S,5S)-3-[(3-hydroxy-4-methoxybenzoyl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Other names Hydroxymethoxycocaine 4′-hydroxy-3′-methoxycocaine parahydroxymetamethoxycocaine
Identifiers
CAS Number	89315-13-9^Y
3D model (JSmol)	Interactive image
InChI InChI=1S/C18H23NO6/c1-19-11-5-6-12(19)16(18(22)24-3)15(9-11)25-17(21)10-4-7-13(20)14(8-10)23-2/h4,7-8,11-12,15-16,20H,5-6,9H2,1-3H3 Key: BHHXESNMOOYSOJ-UHFFFAOYSA-N
SMILES COc(c1)c(O)ccc1C(=O)OC2CC(CC3)N(C)C3C2C(=O)OC
Properties
Chemical formula	C18H23NO6
Molar mass	349.383 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Methylvanillylecgonine or vanillylmethylecgonine is a cocaine analog and metabolite of cocaine found in human urine (possibly with co-ingestion of vanillin-vanilla containing products, as a result of cleavage and binding in vivo but more probably the result of the same metabolic pathways by which vanillylmandelic acid is formed).^[1][2][3]

See also

• Salicylmethylecgonine
• Cocaethylene

References

1. Smith, R. Martin; Poquette, Michael A.; Smith, Paula J. (1984). "Hydroxymethoxybenzoylmethylecgonines: New metabolites of cocaine from human urine". Journal of Analytical Toxicology. 8 (1): 29–34. doi:10.1093/jat/8.1.29. PMID 6708474.
2. Smith, Michael L.; Shimomura, Eric; Paul, Buddha D.; Cone, Edward J.; Darwin, W. David; Huestis, Marilyn A. (March 2010). "Urinary excretion of ecgonine and five other cocaine metabolites following controlled oral, intravenous, intranasal, and smoked administration of cocaine". Journal of Analytical Toxicology. 34 (2): 57–63. doi:10.1093/jat/34.2.57. ISSN 1945-2403.
3. Ramcharitar, V.; Levine, B.; Smialek, JE (1995). Benzoylecgonine and Ecgonine Methyl Ester Concentrations in Urine Specimens. ASTM International.