Inositol-1,4-bisphosphate 1-phosphatase

inositol-1,4-bisphosphate 1-phosphatase
Identifiers
EC no.	3.1.3.57
CAS no.	111070-17-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme inositol-1,4-bisphosphate 1-phosphatase (EC 3.1.3.57) catalyzes the reaction

1D-myo-inositol 1,4-bisphosphate + H₂O ${\displaystyle \rightleftharpoons }$ 1D-myo-inositol 4-phosphate + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase. This enzyme is also called inositol-polyphosphate 1-phosphatase. This enzyme participates in inositol phosphate metabolism and phosphatidylinositol signaling system.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1INP and 1JP4.

References

• Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF (1983). "Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides". Biochem. J. 212 (2): 473–82. doi:10.1042/bj2120473. PMC 1152070. PMID 6309146.
• Connolly TM, Bansal VS, Bross TE, Irvine RF, Majerus PW (1987). "The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes". J. Biol. Chem. 262 (5): 2146–9. doi:10.1016/S0021-9258(18)61629-1. PMID 3029066.
• Inhorn RC, Majerus PW (1987). "Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li⁺, Ca²⁺, and Mn²⁺". J. Biol. Chem. 262 (33): 15946–52. doi:10.1016/S0021-9258(18)47680-6. PMID 2824473.