IHCH-7162

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IHCH-7162
Clinical data
Other namesIHCH7162; Centpyraquin; Compound 69-183
Drug classSerotonin 5-HT1A receptor agonist; Serotonin 5-HT2A receptor weak partial agonist or antagonist; Antipsychotic; Antihypertensive agent
ATC code
  • None
Identifiers
  • 4-(1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)-1-(4-fluorophenyl)butan-1-one
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC22H25FN2O
Molar mass352.453 g·mol−1
3D model (JSmol)
  • C1CC2=CC=CC=C2N3C1CN(CC3)CCCC(=O)C4=CC=C(C=C4)F
  • InChI=1S/C22H25FN2O/c23-19-10-7-18(8-11-19)22(26)6-3-13-24-14-15-25-20(16-24)12-9-17-4-1-2-5-21(17)25/h1-2,4-5,7-8,10-11,20H,3,6,9,12-16H2
  • Key:CDMKFCYALGWSEN-UHFFFAOYSA-N

IHCH-7162, also known as centpyraquin or compound 69-183, is a serotonin receptor modulator related to the partial ergolines.[1][2] It is a serotonin 5-HT1A receptor agonist and a mixed modulator of the serotonin 5-HT2A receptor, acting as a weak partial agonist of G protein signaling and as an antagonist of β-arrestin2 recruitment.[2] The drug has antipsychotic-like, CNS depressant, and antihypertensive effects in animals.[3][4][5][6] IHCH-7172 was developed by researchers in India and first described by the 1970s[1][3][4][5][6] before being studied and described further by a Chinese team in 2024.[2]

See also

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References

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  1. ^ a b Singh H, Chawla AS, Kapoor VK (1985). "Medicinal chemistry research in India". Prog Med Chem. Progress in Medicinal Chemistry. 22: 243–266. doi:10.1016/s0079-6468(08)70232-7. ISBN 978-0-444-80668-0. PMID 2873624.
  2. ^ a b c Chen Z, Yu J, Wang H, Xu P, Fan L, Sun F, Huang S, Zhang P, Huang H, Gu S, Zhang B, Zhou Y, Wan X, Pei G, Xu HE, Cheng J, Wang S (April 2024). "Flexible scaffold-based cheminformatics approach for polypharmacological drug design". Cell. 187 (9): 2194–2208.e22. doi:10.1016/j.cell.2024.02.034. PMID 38552625.
  3. ^ a b Singh GB, Nityanand S, Srimal RC, Rao VA, Jain PC, Dhawan BN (December 1973). "Antihypertensive and central nervous system depressant properties of 3-(gamma-p-fluorobenzoyl propyl) 2,3,4,4a,5,6-hexahydro-1(H)-pyrazino(1,2-a) quinoline hydrochloride (compound 69-183, centpyraquin)". Experientia. 29 (12): 1529–1530. doi:10.1007/BF01943898. PMID 4203916.
  4. ^ a b Singh GB, Srimal RC, Nityanand S, Dhawan BN (1978). "Pharmacological studies on 3-[gamma-(p-fluorobenzoyl)propyl]-2,3,4,4a,5,6-hexahydro-1-(H)-pyrazino (1,2-a) quinoline (compound 69/183). Part I: Hypotensive activity". Arzneimittelforschung. 28 (7): 1087–91. PMID 114185.
  5. ^ a b Srimal RC, Mason DF, Dhawan BN (1978). "Pharmacological studies on 3-[gamma-(p-fluorobenzoyl)propyl]-2,3,4,4a,5,6-hexahydro-1 (H)-pyrazino(1,2-a) quinoline hydrochloride (compound 69/183). Part II: Effect on cardiac dynamics". Arzneimittelforschung. 28 (7): 1092–1095. PMID 582695.
  6. ^ a b Singh GB, Srimal RC, Dhawan BN (1978). "Pharmacological studies on 3-[gamma-(p-fluorobenzoyl)propyl]-2,3,4,4a,5,6-hexahydro-1-(H)-pyrazino ]1,2-a] quinoline hydrochloride (compound 69/183). Part III: Assessment of tranquillising activity". Arzneimittelforschung. 28 (8): 1403–1406. PMID 37855.



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