Flavokavain

Flavokavains (also called flavokawains) are a class of chalconoids found in the kava plant. Currently identified types include flavokavain A, flavokavain B, and flavokavain C.^[1]

• 
  Flavokavain A
• 
  Flavokavain B
• 
  Flavokavain C

A systematic review of studies on kava found evidence that its bioactive compounds, particularly flavokavains, exert antiproliferative and pro-apoptotic effects across multiple cancer models, highlighting its potential chemotherapeutic use especially for epithelial cancers, though research on oral squamous cell carcinoma remains scarce.^[2]

References

1. Zi, Xiaolin; Anne Simoneau (2005-04-15). "Flavokawain A, a Novel Chalcone from Kava Extract, Induces Apoptosis in Bladder Cancer Cells by Involvement of Bax Protein-Dependent and Mitochondria-Dependent Apoptotic Pathway and Suppresses Tumor Growth in Mice". Cancer Research. 65 (8): 3479–3486. doi:10.1158/0008-5472.CAN-04-3803. PMID 15833884.
2. Celentano, Antonio; Tran, Andrew; Testa, Claire; Thayanantha, Krishen; Tan-Orders, William; Tan, Stephanie; Syamal, Mitali; McCullough, Michael J.; Yap, Tami (2019). "The protective effects of Kava (Piper methysticum) constituents in cancers: A systematic review". Journal of Oral Pathology & Medicine. 48 (7): 510–529. doi:10.1111/jop.12900. PMID 31172600.

See also

• Kavalactone
• Kava