Draft:Ling Qi

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  • Comment: Please add links. Only do this for the first use of a term that has an existing Wikipedia page. With these added the page is probably OK for acceptance. Ldm1954 (talk) 12:39, 22 June 2025 (UTC)
  • Comment: Well done on creating the draft, and it may potentially meet the relevant requirements (including WP:GNG, WP:ANYBIO, WP:NPROF) but presently it is not clear that it does.
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Ling Qi, Ph.D. (齐岭) is a Chinese-American biomedical scientist and academic known for his research on endoplasmic reticulum-associated degradation (ERAD) and its role in cellular homeostasis and disease pathogenesis. He is currently the Chair of the Department of Molecular Physiology and Biological Physics at the University of Virginia School of Medicine, where he holds the Andrew P. Somlyo Distinguished Professorship in Molecular Physiology.[1] Qi’s research focuses on the intersection of protein quality control, metabolism, and disease, including diabetes, obesity, and neurodevelopmental disorders.

Early life and education

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Qi received his B.S. in Microbiology from Fudan University in Shanghai. He earned a Ph.D. in Immunology from the University of Maryland, Baltimore County in 2001, where he conducted research under the mentorship of immunologist Suzanne Ostrand-Rosenberg.[2] He then completed postdoctoral training in telomere biology and cancer with Nobel Laureate Carol Greider at Johns Hopkins University (2001–2004),[3] followed by postdoctoral work on transcriptional regulation in metabolism with Marc Montminy, a member of the National Academy of Sciences,[4] at the Salk Institute (2004–2007). After establishing his independent laboratory in 2007, Qi began focusing on cellular stress responses, inflammation, and metabolic regulation.

Career and research

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Qi started research in 2007 at Cornell University’s Division of Nutritional Sciences, where he was promoted to tenured Associate Professor in 2013. He moved to the University of Michigan Medical School in 2016 and was recruited in 2023 to the University of Virginia to lead its Department of Molecular Physiology and Biological Physics.[citation needed]

Qi’s research has focused on the endoplasmic reticulum-associated degradation (ERAD) pathway, particularly the SEL1L-HRD1 complex. His group demonstrated the role of SEL1L-HRD1 ERAD in maintaining ER function and organismal homeostasis in vivo.[5] His work has since expanded to include studies linking ERAD to mitochondrial dynamics in brown adipocytes using 3D imaging techniques.[6] In 2023, Qi’s lab delineated the role of SEL1L-HRD1 ERAD in innate immunity.[7] This study has received expert commentary and analysis.[8][9] More recently, his team recently identification of 11 human patients carrying the genetic variants of SEL1L-HRD1 ERAD[10] and solved the structure of the SEL1L-HRD1 core complex in mammalian cells.[11]

As of 2025, Qi has authored over 100 peer-reviewed publications and 10 invited reviews. According to Google Scholar, his h-index is 55.[12]

Recognition and service

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Qi was elected a Fellow of the American Association for the Advancement of Science (AAAS) in 2021 for “distinguished contributions to the fields of immunometabolism and cellular stress pathways.”[13]

Mentorship and teaching

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Qi has mentored over 100 trainees, including undergraduate students, graduate students, and postdoctoral fellows. He received the SUNY Chancellor’s Award for Excellence in Teaching in 2014.[14]

References

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  1. ^ "Ling Qi, PhD, to Chair UVA's Department of Molecular Physiology and Biological Physics". UVA Health Newsroom. 3 May 2023.
  2. ^ Ostrand-Rosenberg, S (2012). "Coordinated regulation of myeloid cells by tumors". Nature Reviews Immunology. 12 (4): 253–268. doi:10.1038/nri3175. PMC 3587148. PMID 22437938.
  3. ^ "Carol W. Greider – Biographical". NobelPrize.org. Retrieved June 18, 2025.
  4. ^ "Marc Montminy". National Academy of Sciences. Retrieved June 18, 2025.
  5. ^ Sun, S; Shi, G; Han, X (2014). "Sel1L is indispensable for mammalian ERAD, ER homeostasis and survival". Proceedings of the National Academy of Sciences. 111 (5): E582 – E591. doi:10.1073/pnas.1318114111. PMC 3918815. PMID 24453213.
  6. ^ Zhou, Z (2020). "Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes". Science. 368 (6486): 54–60. doi:10.1126/science.aax3878. PMC 7409365. PMID 32193362.
  7. ^ Ji, Yewei; Luo, Yuan; Wu, Yating; Sun, Yao; Zhao, Lianfeng; Xue, Zhen; Sun, Mengqi; Wei, Xiaoqiong; He, Zinan; Wu, Shuangcheng Alivia; Lin, Liangguang Leo; Lu, You; Chang, Lei; Chen, Fei; Chen, Siyu; Qian, Wei; Xu, Xiaoxi; Chen, Shengnuo; Pan, Dongli; Zhou, Zhangsen; Xia, Sheng; Hu, Chih-Chi Andrew; Liang, Tingbo; Qi, Ling (2023). "SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool". Nature Cell Biology. 25 (5): 726–739. doi:10.1038/s41556-023-01138-4. PMID 37142791. Retrieved 2025-06-18.
  8. ^ Gao, Kevin Mingjie; Fitzgerald, Katherine A. (May 2023). "Innate immunity gets an ERAD boost". Nature Cell Biology. 25 (5): 635–636. doi:10.1038/s41556-023-01142-8. PMID 37142792. Retrieved 2025-06-18.
  9. ^ "Perspective: Connecting ERAD with immune regulation". Nature Cell Biology. 25 (5): 641–642. May 2023. doi:10.1038/s41556-023-01139-3. Retrieved 2025-06-18.
  10. ^ Wang, HH (2024). "Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders". Journal of Clinical Investigation. 134 (2): e170054. doi:10.1172/JCI170054. PMC 10786691. PMID 37943610.
  11. ^ Lin, Liangguang Leo; Maldosevic, Emir; Zhou, Linyao Elina; Jomaa, Ahmad; Qi, Ling (2025). "Structure of the SEL1L-HRD1 complex". bioRxiv. doi:10.1101/2025.06.13.659592.
  12. ^ "Ling Qi – Google Scholar Citations". Google Scholar. Retrieved June 18, 2025.
  13. ^ "2021 AAAS Fellows approved by the AAAS Council". Science. 375 (6577): 393–397. 2022. Bibcode:2022Sci...375..393.. doi:10.1126/science.ada0325.
  14. ^ "20 Cornellians win SUNY Chancellor's Awards for Excellence".