The site was also the home for part of the Manhattan Project during World War II.
After two years of renovations by Richard Meier, the building was reopened in 1970 as Westbeth Artists Community for low- to middle-income artists. In addition to affordable artist housing, the complex contains a theater, an art gallery, and a synagogue.
It was declared a National Historic Landmark in 1975.[2][3] The complex was listed a second time on the National Register in 2009, for its high-profile and successful example of adaptive reuse of the property.
The southern viaduct section of the West Side Line railroad passed underneath the building at first floor level. This segment remains in place but is now isolated from the rest of the former railroad viaduct, which is now the High Line elevated park.