BTF3

BTF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LKX, 3MCB
Identifiers
Aliases	BTF3, BETA-NAC, BTF3a, BTF3b, NACB, basic transcription factor 3
External IDs	OMIM: 602542; MGI: 1202875; HomoloGene: 37453; GeneCards: BTF3; OMA:BTF3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.2 Start 73,498,408 bp[1] End 73,505,667 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D1 Start 98,446,404 bp[2] End 98,453,514 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon lactiferous duct human penis left ovary embryo vulva ganglionic eminence oral cavity trabecular bone cartilage tissue Top expressed in epiblast lens ventricular zone ganglionic eminence yolk sac embryo embryo thymus blastocyst uterus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasm nucleus cytosol nascent polypeptide-associated complex polysomal ribosome Biological process protein transport in utero embryonic development regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 689 218490 Ensembl ENSG00000145741 ENSMUSG00000021660 UniProt P20290 Q64152 RefSeq (mRNA) NM_001207 NM_001037637 NM_001393652 NM_001393653 NM_001170540 NM_145455 RefSeq (protein) NP_001032726 NP_001198 NP_001164011 NP_663430 Location (UCSC) Chr 5: 73.5 – 73.51 Mb Chr 13: 98.45 – 98.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor BTF3 is a protein that in humans is encoded by the BTF3 gene.^[5][6][7][8]

Function

This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.^[8]

Interactions

BTF3 has been shown to interact with CSNK2B.^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000145741 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021660 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zheng XM, Black D, Chambon P, Egly JM (April 1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3". Nature. 344 (6266): 556–559. Bibcode:1990Natur.344..556Z. doi:10.1038/344556a0. PMID 2320128. S2CID 4227320.
6. Kanno M, Chalut C, Egly JM (August 1992). "Genomic structure of the putative BTF3 transcription factor". Gene. 117 (2): 219–228. doi:10.1016/0378-1119(92)90732-5. PMID 1386332.
7. Freire MA (January 2005). "Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex". Gene. 345 (2): 271–277. doi:10.1016/j.gene.2004.11.030. PMID 15716105.
8. "Entrez Gene: BTF3 basic transcription factor 3".
9. Grein S, Pyerin W (January 1999). "BTF3 is a potential new substrate of protein kinase CK2". Molecular and Cellular Biochemistry. 191 (1–2): 121–128. doi:10.1023/A:1006806226764. PMID 10094400. S2CID 1057554.

External links

• Human BTF3 genome location and BTF3 gene details page in the UCSC Genome Browser.
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Transcription factor BTF3

Further reading

• Wiedmann B, Sakai H, Davis TA, Wiedmann M (August 1994). "A protein complex required for signal-sequence-specific sorting and translocation". Nature. 370 (6489): 434–440. Bibcode:1994Natur.370..434W. doi:10.1038/370434a0. PMID 8047162. S2CID 4353902.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Grein S, Pyerin W (January 1999). "BTF3 is a potential new substrate of protein kinase CK2". Molecular and Cellular Biochemistry. 191 (1–2): 121–128. doi:10.1023/A:1006806226764. PMID 10094400. S2CID 1057554.
• Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, et al. (May 2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nature Biotechnology. 19 (5): 440–445. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
• Kusumawidjaja G, Kayed H, Giese N, Bauer A, Erkan M, Giese T, et al. (March 2007). "Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells". Cancer Biology & Therapy. 6 (3): 367–376. CiteSeerX 10.1.1.410.5257. doi:10.4161/cbt.6.3.3704. PMID 17312387. S2CID 9044882.
• Symes AJ, Eilertsen M, Millar M, Nariculam J, Freeman A, Notara M, et al. (2013). "Quantitative analysis of BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue". PLOS ONE. 8 (12) e84295. Bibcode:2013PLoSO...884295S. doi:10.1371/journal.pone.0084295. PMC 3874000. PMID 24386364.