ADAM33

ADAM33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R54, 1R55
Identifiers
Aliases	ADAM33, C20orf153, DJ964F7.1, ADAM metallopeptidase domain 33
External IDs	OMIM: 607114; MGI: 1341813; HomoloGene: 11881; GeneCards: ADAM33; OMA:ADAM33 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 3,667,965 bp[1] End 3,682,246 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.26 cM Start 130,892,511 bp[2] End 130,905,734 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in canal of the cervix body of uterus left uterine tube stromal cell of endometrium muscle layer of sigmoid colon ectocervix gastric mucosa Descending thoracic aorta ascending aorta myometrium Top expressed in ascending aorta aortic valve lip umbilical cord sciatic nerve dermis tunica media of zone of aorta muscle of thigh embryo superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity metalloendopeptidase activity protein binding hydrolase activity metallopeptidase activity metal ion binding zinc ion binding Cellular component integral component of membrane membrane Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80332 110751 Ensembl ENSG00000149451 ENSMUSG00000027318 UniProt Q9BZ11 Q08AM2 Q923W9 RefSeq (mRNA) NM_001282447 NM_025220 NM_153202 NM_001163529 NM_033615 RefSeq (protein) NP_001269376 NP_079496 NP_694882 NP_001157001 NP_291093 Location (UCSC) Chr 20: 3.67 – 3.68 Mb Chr 2: 130.89 – 130.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene.^[5][6]

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness.^[7] Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000149451 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027318 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, et al. (January 2002). "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity". Gene. 282 (1–2): 227–236. doi:10.1016/S0378-1119(01)00818-6. PMID 11814695.
6. "Entrez Gene: ADAM33 ADAM metallopeptidase domain 33".
7. Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, et al. (2016-07-21). "Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life". JCI Insight. 1 (11). doi:10.1172/jci.insight.87632. ISSN 0021-9738. PMC 4968941. PMID 27489884.

Further reading

• Holgate ST, Davies DE, Rorke S, Cakebread J, Murphy G, Powell RM, et al. (August 2004). "ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma". Clinical Reviews in Allergy & Immunology. 27 (1): 23–34. doi:10.1385/CRIAI:27:1:023. PMID 15347848. S2CID 23971367.
• Holloway JW, Davies DE, Powell R, Haitchi HM, Keith TP, Holgate ST (August 2004). "The discovery and role of ADAM33, a new candidate gene for asthma". Expert Reviews in Molecular Medicine. 6 (17): 1–12. doi:10.1017/S1462399404007963. PMID 15387895. S2CID 30427584.
• Holgate ST, Yang Y, Haitchi HM, Powell RM, Holloway JW, Yoshisue H, et al. (July 2006). "The genetics of asthma: ADAM33 as an example of a susceptibility gene". Proceedings of the American Thoracic Society. 3 (5): 440–443. doi:10.1513/pats.200603-026AW. PMID 16799089.
• Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, et al. (July 2002). "Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness". Nature. 418 (6896): 426–430. doi:10.1038/nature00878. PMID 12110844. S2CID 4424215.
• Garlisi CG, Zou J, Devito KE, Tian F, Zhu FX, Liu J, et al. (January 2003). "Human ADAM33: protein maturation and localization". Biochemical and Biophysical Research Communications. 301 (1): 35–43. doi:10.1016/S0006-291X(02)02976-5. PMID 12535637.
• Chae SC, Yoon KH, Chung HT (2003). "Identification of novel polymorphisms in the Adam33 gene". Journal of Human Genetics. 48 (5): 278–281. doi:10.1007/s10038-003-0019-1. PMID 12768445.
• Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, et al. (October 2003). "Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations". The Journal of Allergy and Clinical Immunology. 112 (4): 717–722. doi:10.1016/s0091-6749(03)01939-0. PMID 14564349.
• Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, et al. (January 2004). "Crystal structure of the catalytic domain of human ADAM33". Journal of Molecular Biology. 335 (1): 129–137. doi:10.1016/j.jmb.2003.10.037. PMID 14659745.
• Zou J, Zhu F, Liu J, Wang W, Zhang R, Garlisi CG, et al. (March 2004). "Catalytic activity of human ADAM33". The Journal of Biological Chemistry. 279 (11): 9818–9830. doi:10.1074/jbc.M309696200. PMID 14676211.
• Powell RM, Wicks J, Holloway JW, Holgate ST, Davies DE (July 2004). "The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts". American Journal of Respiratory Cell and Molecular Biology. 31 (1): 13–21. doi:10.1165/rcmb.2003-0330OC. PMID 14742294.
• Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Wilson DI, et al. (May 2005). "ADAM33 expression in asthmatic airways and human embryonic lungs". American Journal of Respiratory and Critical Care Medicine. 171 (9): 958–965. doi:10.1164/rccm.200409-1251OC. PMID 15709049.
• Zou J, Zhang R, Zhu F, Liu J, Madison V, Umland SP (March 2005). "ADAM33 enzyme properties and substrate specificity". Biochemistry. 44 (11): 4247–4256. doi:10.1021/bi0476230. PMID 15766253.
• Simpson A, Maniatis N, Jury F, Cakebread JA, Lowe LA, Holgate ST, et al. (July 2005). "Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function". American Journal of Respiratory and Critical Care Medicine. 172 (1): 55–60. doi:10.1164/rccm.200412-1708OC. PMID 15805180.

External links

• The MEROPS online database for peptidases and their inhibitors: M12.244
• Human ADAM33 genome location and ADAM33 gene details page in the UCSC Genome Browser.