A-CHMINACA

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A-CHMINACA
Legal status
Legal status
Identifiers
  • N-(1-adamantyl)-1-(cyclohexylmethyl)indazole-3-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC25H33N3O
Molar mass391.559 g·mol−1
3D model (JSmol)
  • C1CCC(CC1)CN2C3=CC=CC=C3C(=N2)C(=O)NC45CC6CC(C4)CC(C6)C5
  • InChI=1S/C25H33N3O/c29-24(26-25-13-18-10-19(14-25)12-20(11-18)15-25)23-21-8-4-5-9-22(21)28(27-23)16-17-6-2-1-3-7-17/h4-5,8-9,17-20H,1-3,6-7,10-16H2,(H,26,29)
  • Key:ACFKPINHOINOFB-UHFFFAOYSA-N

A-CHMINACA, (ACHMINACA, Adamantyl-CHMINACA, SGT-37), is an indazole-based synthetic cannabinoid that binds to the CB1 and CB2 receptors.[2][3]

It has an EC50 of 159 nM for human CB1 receptors.[4]

Metabolism

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A-CHMINACA is not hydrolized by human carboxylesterases which increases its half-life.[5]

Distribution

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A-CHMINACA has been sold as a designer drug with one sample having been seized by Polish authorities in Lublin.[6]

It was also detected in samples taken in Toronto in 2020.[7]

See also

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References

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  1. ^ NpSG blanket ban[1]
  1. ^ "Anlage NpSG". Einzelnorm (in German). Retrieved 2025-09-10.
  2. ^ "Substance Details Adamantyl-CHMINACA". United Nations : Office on Drugs and Crime. Retrieved September 10, 2025.
  3. ^ Miller JJ, Yazdanpanah M, Colantonio DA, Beriault DR, Delaney SR (Dec 2024). "New Psychoactive Substances: A Canadian perspective on emerging trends and challenges for the clinical laboratory". Clinical Biochemistry. 133–134 110810. Elsevier BV. doi:10.1016/j.clinbiochem.2024.110810. ISSN 0009-9120. PMID 39181179.
  4. ^ Cannaert A, Sparkes E, Pike E, Luo JL, Fang A, Kevin RC, et al. (December 16, 2020). "Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA". ACS Chemical Neuroscience. 11 (24): 4434–4446. doi:10.1021/acschemneuro.0c00644. ISSN 1948-7193. PMID 33253529. Retrieved September 10, 2025.
  5. ^ Wagmann L, Stiller RG, Fischmann S, Westphal F, Meyer MR (July 5, 2022). "Going deeper into the toxicokinetics of synthetic cannabinoids: in vitro contribution of human carboxylesterases" (PDF). Archives of Toxicology. 96 (10). Springer Science and Business Media LLC: 2755–2766. Bibcode:2022ArTox..96.2755W. doi:10.1007/s00204-022-03332-z. ISSN 0340-5761. PMC 9352624. PMID 35788413. Retrieved September 10, 2025.
  6. ^ Dybowski MP, Holowinski P, Typek R, Dawidowicz AL (2021). "Comprehensive analytical characteristics of N-(adamantan-1-yl)-1- (cyclohexylmethyl)-1H-indazole-3-carboxamide (ACHMINACA)" (PDF). Forensic Toxicology. 39 (1): 230–239. doi:10.1007/s11419-020-00547-6. ISSN 1860-8965. Retrieved September 10, 2025.
  7. ^ Scarfone KM, Maghsoudi N, McDonald K, Thompson H, Stefan C, Beriault DR, et al. (August 3, 2022). "Emerging synthetic cannabinoids detected by a drug checking service in Toronto, Canada". Clinical Toxicology. 60 (8): 979–984. doi:10.1080/15563650.2022.2069575. ISSN 1556-3650. PMID 35546568. Retrieved September 10, 2025.