2006 Uzbekistan Cup (Футбол бўйича 2006-йилги Ўзбекистон Кубоги) was a football tournament organized by the Uzbekistan Football Federation, in which 35 clubs participated. Starting from the first round, the tournament was held in a knockout system. The final match took place on 8 November 2006 at the Pakhtakor Central Stadium in Tashkent between Mashʼal and Pakhtakor. Pakhtakor won the cup for the eighth time.